112390-79-1

Basic information

• Product Name: 4-Pyridineacetonitrile,3-hydroxy-(9CI)
• Synonyms: 4-Pyridineacetonitrile,3-hydroxy-(9CI)
• CAS NO: 112390-79-1
• Molecular Formula: C6H7NO2
• Molecular Weight: 125.126
• Product Categories: PYRIDINE
• Mol File: 112390-79-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 175-178 °C(Solv: acetone (67-64-1))
• Boiling Point: 436.5±30.0 °C(Predicted)
• Appearance: /
• Density: 1.250±0.06 g/cm3(Predicted)
• Refractive Index: 1.529
• PKA: 7.94±0.10(Predicted)
• CAS DataBase Reference: 4-Pyridineacetonitrile,3-hydroxy-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridineacetonitrile,3-hydroxy-(9CI)(112390-79-1)
• EPA Substance Registry System: 4-Pyridineacetonitrile,3-hydroxy-(9CI)(112390-79-1)

Safety Data

• Hazardous Substances Data: 112390-79-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H8N2/c1-7-6-8(2-4-9)3-5-10-7/h3,5-6H,2H2,1H3

Upstream product

• 112372-18-6 3-cyanofuro<2,3-c>pyridine 

Relevant articles and documents

Furopyridines. VII. Preparation and Hydrolysis of 2-Cyano and 3-Cyano Derivatives of Furo-, Furo-, and Furopyridine

This paper describes the preparation and hydrolysis of 2-cyano and 3-cyano derivatives of furo-, furo-, and furopyridine.Treatment of furopyridines 1a, 1b and 1c with n-butyllithium in hexane-tetrahydrofuran at -70 deg C and subsequent addition of N,N-dimethylformamide yielded 2-formyl derivatives 2a, 2b and 2c.Dehydration of the oximes 4a, 4b and 4c of 2a, 2b and 2c gave 2-cyano compounds 5a, 5b and 5c, which were hydrolyzed to give 2-carboxylic acids, 6a, 6b and 6c, respectively.Reaction of 3-bromo compounds 7a, 7b and 7c with copper(I) cyanide in N,N-dimethylformamide afforded 3-cyano derivatives 8a, 8b and 8c.Alkaline hydrolysis of 8a, 8b and 8c gave compounds formed by fission of the 1-2 bond of furopyridines 9a, 9b and 9c, while acidic hydrolysis gave the corresponding carboxamides, 10a, 10b and 10c.