112391-52-3

Upstream product

• 2049-80-1 (2-propenyl)propanedioic acid diethyl ester 
• 139566-47-5 diethyl (prop-2'-en-1'-yl)(3''-phenylprop-2''-en-1''-yl)propanedioate 
• 21087-29-6 trans-3-phenylprop-2-enyl chloride 

Downstream Products

• 1453416-56-2 (E)-2-allyl-5-phenyl-N-(p-tolyl)pent-4-enamide 
• 112391-55-6 Toluene-4-sulfonic acid (E)-2-allyl-5-phenyl-pent-4-enyl ester 
• 112391-59-0 3-prop-2-enyl-6-phenylhex-5-enoic acid 
• 112391-57-8 (E)-3-Allyl-6-phenyl-hex-5-enenitrile 
• 93681-86-8 (1R,1aR,3R)-3-Allyl-1-phenyl-1,1a,2,3-tetrahydro-4,9a,9b-triaza-cyclopropa[a]anthracen-9-one 
• 93681-87-9 (1aR,3R)-3-((E)-3-Phenyl-allyl)-1,1a,2,3-tetrahydro-4,9a,9b-triaza-cyclopropa[a]anthracen-9-one 
• 101126-01-6 3-amino-2-(1-phenylhepta-1,6-dien-4-yl)quinazolin-4(3H)-one 
• 93681-79-9 methyl N-(5-phenyl-2-prop-2-enylpent-4-enoyl)anthranilate 
• 112391-53-4 2-allyl-5-phenyl-4-penten-1-ol 

Relevant academic research and scientific papers

Study on the total synthesis of velbanamine: Chemoselective dioxygenation of alkenes with PIFA via a stop-and-flow strategy

A "stop-and-flow" strategy was developed for the chemoselective dioxygenation of alkenes with a PIFA-initiated cyclization. This method is conceived for the desymmetrization of seco-diene, and a series of substituted 5-hydroxymethyl-γ-lactones were constructed after hydrolysis. This strategy also differentiates terminally substituted alkenes and constitutes a potentially novel synthetic approach for the efficient synthesis toward velbanamine.

Intramolecular Reactions of N-Nitrenes with Alkenes

Oxidation of 2-but-1-enyl- and 2-(1-phenylbut-1-enyl)-3-aminoquinazolin-4(3H)-ones (8) and (10), respectively, generates the corresponding N-nitrenes which are trapped intramolecularly by the double bonds.The results from competitive intramolecular trapping of the N-nitrene by different double bonds in 3-aminoquinazolones bearing bifurcated chains in position 2 indicate that these intramolecular nitrene additions are non-concerted and, as in the corresponding intramolecular addition to aromatic rings, proceed via 7-membered transition states with the nitrene functioning as an electrophile.