1124-69-2

Usage

Molecular structure

A tetrahydropyridine ring with four methyl groups attached at the 2,2,6,6 positions

Use in research

Induces Parkinson's disease-like symptoms in animal models for studying the disease

Mechanism of action

Targets the dopaminergic system in the brain, leading to the degeneration of dopaminergic neurons and the onset of Parkinsonian motor deficits

Motor impairments caused by TMT exposure

Tremors, rigidity, and bradykinesia

Value in Parkinson's disease research

Provides a valuable tool for understanding the underlying mechanisms of the disease and testing potential therapeutic interventions

InChI:InChI=1/C9H17N/c1-8(2)6-5-7-9(3,4)10-8/h5-6,10H,7H2,1-4H3

Upstream product

• 3264-93-5 2,2,6,6-tetramethyl-1,2,5,6-tetrahydropyridine-1-oxyl 
• 36768-62-4 4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE 
• 2403-88-5 4-hydroxy-2,2,6,6-tetramethylpiperidine 
• 67845-89-0 4-bromo-2,2,6,6-tetramethylpiperidine 

Relevant academic research and scientific papers

Synthesis of 2,2,6,6-tetramethylpiperidine derivatives

Diazotization of 4-amino-2,2,6,6-tetramethylpiperidine in acetic or sulfuric acid affords 2,2,6,6-tetramethyl-1,2,3,6-tetrahydropyridine in high yield. Under the same conditions, the corresponding nitroxyl radical transforms into 4-hydroxy-2,2,6,6-tetrame

A simple method of preparation of 7-alkyl-7-azabicyclo[2.2.1] heptanes

Action of triphenylphosphine - carbon tetrachloride on the trans-4-alkylaminocyclohexanols leads to 7-alkyl-7-azabicyclo[2.2.1]heptanes in the good yields. The starting aminoalcohols are easily available from the monoethylene ketal of 1,4-cyclohexanedione and primary amines in a four step process without isolation of intermediates.

A Reaction of Nitroxides with Ethyl Mercaptane: A Mild Method for the Conversion of Nitroxides into Their Corresponding Amines

The mild reduction of the nitroxides 1a-j to the corresponding sterically hindered amines 2a-j by means of ethyl mercaptane is reported.The reaction mixtures of 1a,b,g were analyzed by glc/ms.