1124-95-4

Usage

Uses

Used in Pharmaceutical Industry:
2-AZASPIRO[4.4]NONANE-1,3-DIONE is used as a key building block for the synthesis of various pharmaceuticals due to its ability to form functionalized heterocyclic compounds, which are essential in the development of new drugs with specific therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical sector, 2-AZASPIRO[4.4]NONANE-1,3-DIONE serves as an important intermediate in the creation of agrochemicals, contributing to the development of effective pesticides, herbicides, and other crop protection agents.
Used in Organic Synthesis:
2-AZASPIRO[4.4]NONANE-1,3-DIONE is utilized as a versatile intermediate in organic synthesis for the production of a wide range of organic compounds, showcasing its adaptability and value in chemical research and development.

InChI:InChI=1/C8H11NO2/c10-6-5-8(7(11)9-6)3-1-2-4-8/h1-5H2,(H,9,10,11)

Upstream product

• 120-92-3 cyclopentanone 
• 62953-74-6 ethyl 2-cyano-2-(1-cyanocyclopentyl)acetate 
• 62953-73-5 1-(carboxymethyl)cyclopentanecarboxylic acid 
• 5407-83-0 ethyl 2-cyano-2-cyclopentylideneacetate 
• 5623-90-5 2-oxaspiro[4.4]nonane-1,3-dione 

Relevant academic research and scientific papers

Spirosuccinimides as potential anticonvulsants

A series of spirosuccinimides was synthesized and evaluated for anticonvulsant activity. The study was designed to apply the Topliss approach to structure-activity correlations in this novel series of 2-substituted-2-azaspiro[4.4]nonane-1,3-diones and 2,4-disubstituted-2- azaspiro[4.4]nonae-1,3-diones. While no correlation was noted with the 2-substituted derivatives, a good correlation was obtained in the 2,4-disubstituted series, indicating that anticonvulsant activity was related to increasing π values. The results of these anticonvulsant tests are presented and a rational approach to the structure-activity relationships of spirosuccinimides is provided.

AMIDOALKYLPIPERAZINYL DERIVATIVES FOR THE TREATMENT OF CENTRAL NERVOUS SYSTEM DISEASES

The invention relates to novel amidoalkylpiperazinyl derivatives of tricyclic heterocyclic systems of general formula (I), wherein Z represents -NH- and X represents -S-, or Z represents -S- and X represents >C=C1 represents H or -CH3, R6 and R7 both represent H, n is an integer from 0 to 4 inclusive, G represents a cyclic amide or imide moiety, and optical isomers, geometric isomers, and pharmaceutically acceptable salts thereof. The compounds may be useful for the treatment and/or prevention of the central nervous system disorders.

SYNTHESIS OF SPIROIMIDES OF PHARMACOLOGIC INTEREST

Spiroimides of fluorene, indane and cyclopentane have been prepared as potential anticonvulsant agents.Certain azaspirane derivatives of fluorene are also reported.