112402-18-3Relevant academic research and scientific papers
Synthetic studies of indoles and related compounds. XXVII. A new synthesis of crenatine from ethyl indole-2-carboxylate
Murakami,Yokoyama,Aoki,Suzuki,Sakurai,Shinohara,Miyagi,Kimura,Takahashi,Watanabe,Ohmoto
, p. 2189 - 2195 (1991)
Crenatine (1a), which is a member of a new class of β-carboline alkaloids having an oxygen functionality at the 4-position, was synthesized starting from ethyl 1-benzylindole-2-carboxylate (12a) via cyclization of an elaborated C2-substituent to the 3-position of the indole nucleus and aluminum chloride-catalyzed debenzylation of the protected indolic nitrogen. 1-Ethyl-4-hydroxy-9-methyl-β-carboline (26b), a positional isomer of crenatine with regard to the methyl group, was also synthesized through the same methodology.
A NEW ROUTE TO 4-OXYGENATED β-CARBOLINES: THE TOTAL SYNTHESIS OF CRENATINE
Murakami, Yasuoki,Yokoyama, Yuusaku,Aoki, Chiyoko,Miyagi, Chiemi,Watanabe, Toshiko,Ohmoto, Taichi
, p. 875 - 878 (2007/10/02)
Crenatine, a new type of β-carboline alkaloid having an oxygen function at its C4-position, was synthesized using ethyl 1-benzylindole-2-carboxylate as a starting material via cyclization of C2-substituent to C3-position of indole nucleus and AlCl3-catalyzed debenzylation for N-protected indoles.
