112404-80-5Relevant academic research and scientific papers
Zeolite-catalyzed environmentally friendly tetrahydropyranylation of alcohols and phenols
Hegedues, Adrienn,Vigh, Ilona,Hell, Zoltan
, p. 4145 - 4152 (2004)
A simple and environmentally friendly tetrahydropyranylation of various alcohols and phenols at room temperature was elaborated by using a small pore size zeolite. The material is also suitable for the deprotection but with less efficiency.
Design, Synthesis, and Evaluation of Novel 2,6-Disubstituted Phenol Derivatives as General Anesthetics
Qin, Linlin,Ren, Lei,Wan, Songlin,Liu, Guoliang,Luo, Xinfeng,Liu, Zhenhong,Li, Fangqiong,Yu, Yan,Liu, Jianyu,Wei, Yonggang
supporting information, p. 3606 - 3617 (2017/05/19)
A novel series of optically active 2,6-disubstituted alkylphenols with improved anesthetic profiles compared to widely used propofol were synthesized. The incorporation of the cyclopropyl group not only increased the steric effect but also introduced ster
PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF
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Paragraph 0150; 0151; 0152; 0153, (2016/05/02)
The present invention relates to a phenol derivative and the preparation method and use in medicine thereof, and particular to a phenol derivative represented by general formula (A) or a stereoisomer, a solvate, a metabolite, a prodrug, a pharmaceutically
PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF
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Paragraph 0684; 0686; 0687-0689, (2016/10/10)
The present invention relates to a phenol derivative and the preparation method and use in medicine thereof, and particular to a phenol derivative represented by general formula (A) or a stereoisomer, a solvate, a metabolite, a prodrug, a pharmaceutically
Isopropyl-phenol derivative and preparation method therefor
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Paragraph 0187; 0188; 0189; 0190; 0191, (2016/10/17)
The invention relates to an isopropyl-phenol derivative and a preparation method therefor, in particular to a compound as shown in formula (I) and a novel preparation method of an intermediate of the compound.
SUBSTITUENT MODIFICATION IN TRI-O-THYMOTIDE AND ITS EFFECTS ON HOST GEOMETRY AND GUEST ENCLATHRATION. 1. SYNTHESIS
Harris, Thomas D.,Oruganti, Subra R.,Davis, Lawrence M.,Keehn, Philip M.,Green, Bernard S.
, p. 1519 - 1540 (2007/10/02)
A new synthesis is described for the preparation of tri-o-thymotide (1, TOT) and some TOT analogues.The methodology is based on the sequential coupling of appropriately substituted and protected salicylic acid monomers followed by cyclization of the deprotected open-chain trimers.A variety of protecting methodologies and coupling sequences are disscussed.The procedure seems generally applicable for the preparation of salicylides and has been used to prepare TOT in 25percent overall yield (for the coupling-deprotection-coupling-deprotection-cyclization sequence).In addition, two new modified TOT-analogues 9 (25percent), and 10 (14percent) were prepared in which the isopropyl group(s) ortho to the phenolic units in TOT is replaced by one (9) or two (10) ethyl groups.A third analogue 66, where the methyl group ortho to the carboxyl group is removed in one of the salicylic acid monomer units of TOT, requires only the last cyclization step for completion of its synthesis.This methodology represents an important breakthrough for the controlled preparation of selected thymotide (salicylide) trimers and allows easy access to a variety of modified thymotides (salicylides) for structural, conformational and host-guest studies.
