1124157-62-5Relevant academic research and scientific papers
Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors
Porter, John,Payne, Andrew,de Candole, Ben,Ford, Daniel,Hutchinson, Brian,Trevitt, Graham,Turner, James,Edwards, Chloe,Watkins, Clare,Whitcombe, Ian,Davis, Jeremy,Stubberfield, Colin
, p. 230 - 233 (2009)
Anti-apoptotic Bcl-2 protects cells from apoptosis by binding to pro-apoptotic members of the Bcl-2 family thereby playing a role in tumour survival in response to chemo- or radiation therapy. We describe a series of phenyl pyrazoles that have high affini
