1124196-02-6Relevant articles and documents
SALTS OF MONTELUKAST AND PROCESS THEREFOR
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Page/Page column 7; 9, (2009/04/25)
The present invention relates to new salts (II) of Montelukast (I) and process for preparing these salts where B is ammonia, benzylamine or phenyl hydrazine. The invention also provides a process for preparation amine salts comprising (a) dissolving/ suspending the Montelukast free acid of formula (I) in an organic solvent (b) reacting with an amine (c) isolating the amine salt of formula (II) by adding optionally another anti-solvent, and (d) optionally drying the isolated solid under vacuum. The invention provides a process for preparation of sodium salt of montelukast acid comprising lowering pH of aqueous solution of amine salt of montelukast having formula II to 5.0±0.5, raising pH to above 8.0 using source of sodium ion, and isolating, the sodium salt by crystallization.