1124258-92-9

Basic information

• Product Name: C₁₀H₁₂O₂
• Synonyms: C₁₀H₁₂O₂
• CAS NO: 1124258-92-9
• Molecular Weight: 164.204
• Mol File: 1124258-92-9.mol

Chemical Properties

• CAS DataBase Reference: C₁₀H₁₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₀H₁₂O₂(1124258-92-9)
• EPA Substance Registry System: C₁₀H₁₂O₂(1124258-92-9)

Safety Data

• Hazardous Substances Data: 1124258-92-9(Hazardous Substances Data)

Upstream product

• 1124258-91-8 (R,E)-tert-butyl((5-((4-methoxybenzyl)oxy)-4-methyl-4-phenylpent-2-en-1-yl)oxy)dimethylsilane 

Downstream Products

• 28968-34-5 (R)-3-hydroxy-2-methyl-2-phenylpropanoic acid 

Relevant articles and documents

Enantioselective Synthesis of Functionalized Quaternary Stereocenters

An enantioselective synthesis of functionalized quaternary stereocenters was developed from amino alcohol derived (bromoalkylidene)morpholinones. Stereoselective cross-coupling of the morpholinones with arylboronic acids or alkyl trifluoroborates provided a variety of disubstituted alkylidenemorpholinones. A highly stereoselective Prins reaction of the cross-coupling products generated the target quaternary stereocenter. The Prins products are readily converted into a variety of acyclic, enantiomerically enriched, functionalized building blocks with a quaternary stereocenter.

New general method for regio- and stereoselective allylic substitution with aryl and alkenyl coppers derived from grignard reagents

Allylic substitution with sp2-carbon reagents (aryl and alkenyl anions) was realized by using allylic picolinates and copper reagents derived from RMgBr and CuBr-Me2S to afford anti SN2 products regioand stereoselectively. Steric and electronic factors in the reagents and the size of the methylene substituents around the allylic moiety marginally affected the selectivity. The reaction system was compatible with alkyl reagents as well. Furthermore, the substitution was applied to construction of a quaternary center and synthesis of (-)-sesquichamaenol. Electron-withdrawing nature of the pyridyl group and chelation of the C(=O)-C5H4N to MgBr2 generated in situ were found to be responsible for the high efficiency of the substitution.