1124276-02-3Relevant academic research and scientific papers
Reactivity of γ-hydroxy-α-acetylenic esters with amines: Facile synthesis of the optically active 4-amino-2(5H)-furanones
Zhou, Li-Hong,Yu, Xiao-Qi,Pu, Lin
, p. 2013 - 2017 (2009)
A convenient synthesis of the optically active 4-amino-2(5H)-furanones is discovered by combining an asymmetric alkyne addition to aldehydes and a subsequent aliphatic amine addition. Both steps can be conducted at room temperature and the products are obtained with high enantioselectivity (84-90% ee). The 4-amino-2(5H)-furanones are also found to undergo very facile electrophilic substitution reactions.
