1124292-29-0Relevant academic research and scientific papers
De novo asymmetric synthesis of cladospolide B-D: Structural reassignment of cladospolide D via the synthesis of its enantiomer
Xing, Yalan,O'doherty, George A.
, p. 1107 - 1110 (2009)
The enantioselective synthesis of cladospolide B, C, and (ent)-cladospolide D has been achieved in 11-15 steps from 1-nonyne. The route relies upon an alkyne zipper reaction to relay an ynone and dienoate functional groups across a nine carbon fragment, which enables a highly enantioselective Noyori ynone reduction and a diastereo-and regioselective Sharpless dihydroxylation of a dienoate. In addition to being a flexible approach to three members of the cladospolide natural products, this route for the first time correctly established the structure for cladospolide D.
Structure investigations of (ent)-cladospolide d by de novo synthesis and kinetic and thermodynamic isomerization
Xing, Yalan,Penn, John H.,O'Doherty, George A.
experimental part, p. 2847 - 2854 (2010/03/25)
The de novo asymmetric synthesis of cladospolides B and C and (ent)-cladospolide D has been achieved from achiral non-1-yne. The 11-13-step route relies upon a Noyori reduction and a KAPA promoted alkyne zipper reaction to relay an achiral functionality a
