112447-64-0Relevant academic research and scientific papers
SYNTHESIS OF PYRAZOLE, 1,3,4-THIADIAZOLE, AND 1,2,4-TRIAZOLE DERIVATIVES BY CONDENSATION OF 1,3-DIOXO COMPOUNDS WITH THIOSEMICARBAZIDE DERIVATIVES
Zelenin, K. N.,Solod, O. V.,Alekseev, V. V.,Pekhk, T. I.,Kuznetsova, O. B.,et al.
, p. 1051 - 1060 (2007/10/02)
The reaction of β-diketones with 2-unsubstituted thiosemicarbazides leads to the formation of the corresponding 1-thiocarbamoyl-5-hydroxy-2-pyrazolines, which readily undergo aromatization to give pyrazoles, while the reaction of benzoylacetaldehyde leads to the formation of the corresponding hydrazone.Acetylacetone 2-methyl- and 2,4-dimethylthiosemicarbazones are inclined to undergo tautomerization and, depending on the conditions, can exist in enehydrazine, hydrazone, 1,2,4-triazoline, and 1,3,4-thiadiazoline forms or mixtures of these forms.Upon heating these substances are converted to mixtures of the 1,3,5-trimethylpyrazole and the corresponding 1,2,4-triazoline-5-thione.The structures of the compounds were studied by means of IR and 1H, 13C, and 15N NMR spectroscopy and mass spectrometry.
Reinvestigation of the Reaction of 4-Aryl-2-hydrazinothiazoles with Dibenzoylmethane
Vaid, R. K.,Kaushik, B.,Dhindsa, G. S.
, p. 371 - 373 (2007/10/02)
The reaction of 2-hydrazino-4-arylthiazoles (I) with dibenzoylmethane in ethanol gave exclusively 4-aryl-2-(3',5'-diphenylpyrazol-1'-yl)thiazoles (III) via a cyclization, and not the possible condensate 3-aryl-5,7-diphenylthiazolo1,2,4
