112459-65-1

Upstream product

• 90319-52-1 (4R)-phenyl-2-oxazolidinone 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 85711-14-4 (R)-2-amino-2-cyclohexylethanol hydrochloride 
• 750594-55-9 tert-Butyl-{(R)-2-cyclohexyl-3-[(2S,5R)-2-isopropyl-5-methyl-cyclohex-(E)-ylidene]-propoxy}-dimethyl-silane 
• 750594-68-4 {(R)-1-Cyclohexyl-2-[(2S,5R)-2-isopropyl-5-methyl-cyclohex-(E)-ylidene]-ethyl}-carbamic acid methyl ester 
• 750594-67-3 (R)-2-Cyclohexyl-3-[(2S,5R)-2-isopropyl-5-methyl-cyclohex-(E)-ylidene]-propionic acid 
• 750594-82-2 ((R)-1-Cyclohexyl-2-hydroxy-ethyl)-carbamic acid methyl ester 

Downstream Products

• 94418-33-4 (4R)-3-((E,E)-2',8',10'-undecatrienoyl)-4-cyclohexyl-2-oxazolidinone 
• 94418-29-8 (4R)-3-((E,E)-2',7',9'-decatrienoyl)-4-cyclohexyl-2-oxazolidinone 
• 227602-37-1 (4R)-N-bromoacetyl-4-cyclohexyloxazolidin-2-one 
• 1356455-19-0 3-((R)-4-cyclohexyl-2-oxooxazolidin-3-yl)-5-(3,3-dimethylbut-1-ynyl)thiophene-2-carboxylic acid 
• 94417-68-2 (R)-4-Cyclohexyl-3-((1S,4aR,8aS)-1,2,4a,5,6,7,8,8a-octahydro-naphthalene-1-carbonyl)-oxazolidin-2-one 
• 94481-94-4 (4R)-3-((4'R,5'R,6'S)-bicyclo<4.4.0>decene-4'-carbonyl)-4-cyclohexyl-2-oxazolidinone 
• 94418-36-7 (R)-4-Cyclohexyl-3-((3aS,4S,7aR)-2,3,3a,4,5,7a-hexahydro-1H-indene-4-carbonyl)-oxazolidin-2-one 
• 94482-04-9 (4R)-3-((4'R,5'R,6'S)-bicyclo<4.3.0>nonene-4'-carbonyl)-4-cyclohexyl-2-oxazolidinone 
• 227602-29-1 (4R)-N-<5,5-(trimethylenedithio)-2(E),7(E),9-decatrienoyl>-4-cyclohexyloxazolidin-2-one 
• 227602-34-8 (4R)-N-diethoxyphosphonoacetyl-4-cyclohexyloxazolidin-2-one 

Relevant academic research and scientific papers

2,3,5-TRISUBSTITUTED THIOPHENE COMPOUNDS AND USES THEREOF

The present invention provides a compound of formula (I) a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

A stereodivergent approach to amino acids, amino alcohols, or oxazolidinones of high enantiomeric purity

(-)-Menthone, an inexpensive chiral auxiliary, was used to prepare both enantiomers of α-amino acids, amino alcohols, or oxazolidinones. The sequence includes the SN2′ displacement by a cuprate reagent and a Curtius rearrangement as key steps.

DIASTEREOFACIAL SELECTIVITY IN INTRAMOLECULAR DIELS-ALDER REACTIONS OF CHIRAL TRIENE-N-ACYLOXAZOLIDONES

Excellent diasterofacial selection has been observed in asymmetric Diels-Alder cycloadditions of E,E-triene-imides 3 and 6.