112506-90-8 Usage
General Description
6-CHLORO-9-(5-DEOXY-D-RIBOFURANOSYL)PURINE is a chemical compound that belongs to the purine family. It is a modified form of the nucleoside adenosine, where the hydroxyl group at position 5 of the ribose ring has been removed and a chlorine atom has been added at position 6 of the purine ring. 6-CHLORO-9-(5-DEOXY-D-RIBOFURANOSYL)PURINE is commonly used as a building block for the synthesis of nucleoside analogues, which are used as antiviral and anticancer drugs. Its modified structure gives it unique pharmacological properties and makes it an important compound in medicinal chemistry research.
Check Digit Verification of cas no
The CAS Registry Mumber 112506-90-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,2,5,0 and 6 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 112506-90:
(8*1)+(7*1)+(6*2)+(5*5)+(4*0)+(3*6)+(2*9)+(1*0)=88
88 % 10 = 8
So 112506-90-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H11ClN4O3/c1-4-6(16)7(17)10(18-4)15-3-14-5-8(11)12-2-13-9(5)15/h2-4,6-7,10,16-17H,1H3/t4-,6-,7-,10?/m1/s1
112506-90-8Relevant academic research and scientific papers
Synthesis of Nucleosides through Direct Glycosylation of Nucleobases with 5-O-Monoprotected or 5-Modified Ribose: Improved Protocol, Scope, and Mechanism
Downey, A. Michael,Pohl, Radek,Roithová, Jana,Hocek, Michal
supporting information, p. 3910 - 3917 (2017/03/27)
Simplifying access to synthetic nucleosides is of interest due to their widespread use as biochemical or anticancer and antiviral agents. Herein, a direct stereoselective method to access an expansive range of both natural and synthetic nucleosides up to a gram scale, through direct glycosylation of nucleobases with 5-O-tritylribose and other C5-modified ribose derivatives, is discussed in detail. The reaction proceeds through nucleophilic epoxide ring opening of an in situ formed 1,2-anhydrosugar (termed “anhydrose”) under modified Mitsunobu reaction conditions. The scope of the reaction in the synthesis of diverse nucleosides and other 1-substituted riboside derivatives is described. In addition, a mechanistic insight into the formation of this key glycosyl donor intermediate is provided.
