112528-83-3

Basic information

• Product Name: 2H-Pyran, tetrahydro-2-[(1-methyl-3-phenyl-2-propenyl)oxy]-, (E)-
• CAS NO: 112528-83-3
• Molecular Formula: C15H20O2
• Molecular Weight: 232.323
• Mol File: 112528-83-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2H-Pyran, tetrahydro-2-[(1-methyl-3-phenyl-2-propenyl)oxy]-, (E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Pyran, tetrahydro-2-[(1-methyl-3-phenyl-2-propenyl)oxy]-, (E)-(112528-83-3)
• EPA Substance Registry System: 2H-Pyran, tetrahydro-2-[(1-methyl-3-phenyl-2-propenyl)oxy]-, (E)-(112528-83-3)

Safety Data

• Hazardous Substances Data: 112528-83-3(Hazardous Substances Data)

Upstream product

• 57188-99-5 3-butyn-2-yl tetrahydropyranyl ether 
• 591-50-4 iodobenzene 

Downstream Products

• 112573-95-2 (E)-(3-methylhexa-1,5-dien-1-yl)benzene 
• 73222-65-8 1-methyl-3-phenylhexa-1,5-diene 
• 40486-72-4 trans-3-(Methylthio)-1-phenyl-1-butene 
• 112528-87-7 [(E)-1-(1,1-Dimethyl-allyl)-but-2-enyl]-benzene 
• 112528-86-6 ((E)-3,4,4-Trimethyl-hexa-1,5-dienyl)-benzene 
• 112528-89-9 [(E)-1-(2-Methyl-allyl)-but-2-enyl]-benzene 
• 112528-88-8 ((E)-3,5-Dimethyl-hexa-1,5-dienyl)-benzene 

Relevant articles and documents

Synthesis of an artificial HMG-CoA reductase inhibitor NK-104 via a hydrosilylation-cross-coupling reaction

The hydrosilylation of t-butyl (3R,5S)-3,5-isopropylidenedioxy-6-heptynoate with ClMe2SiH and a platinum catalyst, t-Bu3P·Pt(CH2 = CHSiMe2)2O, gave an (E)-vinylsilane in high yield with high regioselectivity. A subsequent cross-coupling reaction with an aryl halide afforded t-butyl (3R,5S,6E)-7-aryl-3,5-isopropylidene-dioxy-6-heptenoate. This sequence was applied to the synthesis of a potent HMC-CoA reductase inhibitor, NK-104.