112529-18-7

Basic information

• Product Name: 1,O(6)-ethanoguanosine
• Synonyms: 1,O(6)-ethanoguanosine
• CAS NO: 112529-18-7
• Molecular Formula: C12H16N5O5+
• Molecular Weight: 310.28594
• Mol File: 112529-18-7.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 525.5°Cat760mmHg
• Flash Point: 271.6°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 3.08E-13mmHg at 25°C
• CAS DataBase Reference: 1,O(6)-ethanoguanosine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,O(6)-ethanoguanosine(112529-18-7)
• EPA Substance Registry System: 1,O(6)-ethanoguanosine(112529-18-7)

Safety Data

• Hazardous Substances Data: 112529-18-7(Hazardous Substances Data)

Usage

Chemical compound

A substance formed by the modification of the DNA base guanosine at its O(6) position, resulting in the addition of an ethano group.

Formation

Occurs due to exposure to various chemical agents or environmental carcinogens, leading to DNA damage.

Potential biomarker

Identified for exposure to harmful agents and is being studied as a marker for assessing DNA damage in cells.

Role in DNA adduct formation

Found to play a role in the formation of DNA adducts, which can contribute to mutagenesis and carcinogenesis.

Ongoing research

Being studied to further understand its potential impact on human health and its implications for the development of novel biomarkers and therapeutic interventions.

Structural modification

The addition of an ethano group to the O(6) position of guanosine alters the structure and function of the DNA molecule.

DNA damage

The formation of 1,O(6)-ethanoguanosine is associated with DNA damage, which can lead to mutations and potentially cancerous cells.

Environmental exposure

The modification of guanosine to form 1,O(6)-ethanoguanosine can occur due to exposure to environmental carcinogens, such as tobacco smoke or certain industrial chemicals.

Detection methods

Various analytical techniques, such as mass spectrometry or immunoassays, can be used to detect and quantify 1,O(6)-ethanoguanosine in biological samples.

Therapeutic implications

Understanding the role of 1,O(6)-ethanoguanosine in DNA damage and carcinogenesis may lead to the development of new therapeutic strategies for cancer prevention and treatment.

InChI:InChI=1/C12H15N5O5/c13-12-15-9-6(10-16(12)1-2-21-10)14-4-17(9)11-8(20)7(19)5(3-18)22-11/h4-5,7-8,11,13,18-20H,1-3H2/p+1/b13-12-/t5-,7-,8-,11?/m1/s1