112539-35-2Relevant academic research and scientific papers
Two-Step Synthesis of Blue Luminescent (Pyrrol-3-yl)-1H-(aza)indazoles Based on a Three-Component Coupling-Cyclocondensation Sequence
Nordmann, Jan,Eierhoff, Svenja,Deni?en, Melanie,Mayer, Bernhard,Müller, Thomas J. J.
, p. 5128 - 5142 (2015)
(Pyrrol-3-yl)-1H-(aza)indazoles can be efficiently prepared by a two-step process that consists of a consecutive three-component coupling-cyclocondensation synthesis to give ortho-halo-3-acylpyrrol-3-yl-substituted (hetero)arenes followed by a cyclization
Efficient consecutive four-component synthesis of 5-acylpyrid-2-ones initiated by copper-free alkynylation
Nordmann, Jan,Breuer, Natascha,Mueller, Thomas J. J.
, p. 4303 - 4310 (2013)
A one-pot, consecutive, four-component synthesis of 5-acylpyrid-2-ones initiated by Pd/cataCXium ABn catalysis proceeds under mild reaction conditions and in good yields, with a broad scope of three points of diversity. This sequence is superio
Synthesis of 3-(2-quinolyl) chromones from ynones and quinoline: N -oxides via tandem reactions under transition metal- And additive-free conditions
Liu, Jing,Ba, Dan,Chen, Yanhui,Wen, Si,Cheng, Guolin
, p. 4078 - 4081 (2020)
A novel method for the synthesis of 3-(2-quinolyl) chromones through a tandem [3+2] cycloaddition/ring-opening/O-arylation from ynones and quinoline N-oxides has been developed. This protocol proceeds under transition metal- and additive-free conditions a
Base-Promoted Michael Addition/Smiles Rearrangement/ N-Arylation Cascade: One-Step Synthesis of 1,2,3-Trisubstituted 4-Quinolones from Ynones and Sulfonamides
Liu, Jing,Ba, Dan,Lv, Weiwei,Chen, Yanhui,Zhao, Zemin,Cheng, Guolin
, p. 213 - 223 (2020)
A general, practical, and environmentally friendly protocol to synthesize 1,2,3-trisubstituted 4-quinolones from readily available ynones and sulfonamides was developed. The construction of one C?C bond and two C?N bonds via cleavage of one N?S, one C?S,
Bifunctional Borane Catalysis of a Hydride Transfer/Enantioselective [2+2] Cycloaddition Cascade
Zhang, Ming,Wang, Xiao-Chen
supporting information, p. 17185 - 17190 (2021/07/06)
Herein, we present a mild and efficient method for synthesizing enantioenriched tetrahydroquinoline-fused cyclobutenes through a cascade reaction between 1,2-dihydroquinolines and alkynones with catalysis by chiral spiro-bicyclic bisboranes. The bisborane
Methylation Alkynylation of Terminal Alkenes via 1,2-Alkynyl Migration Using Dicumyl Peroxide as the Methyl Source
Qin, Yi-Qun,Chen, De,Liu, Liang,Zhang, Jia-Jia,Peng, Xin-Ju,Luo, Yong-Yue,Deng, Wei,Xiang, Jiannan
, p. 4700 - 4708 (2021/08/31)
The metal-free oxidative alkene methylation/alkynylation of 1,4-enyn-3-ols with an organic peroxide as the methyl source has been developed, which provides straightforward and practical access to the challenging quaternary-carbon-containing but-3-yn-1-one
Selective Insertion of Alkynes into C-C σ Bonds of Indolin-2-ones: Transition-Metal-Free Ring Expansion Reactions to Seven-Membered-Ring Benzolactams or Chromone Derivatives
Wang, Mengdan,Yang, Yajie,Song, Bo,Yin, Liqiang,Yan, Shuhui,Li, Yanzhong
, p. 155 - 159 (2020/01/03)
An unprecedented ring expansion reaction of indolin-2-ones with alkynyl ketones under transition-metal-free conditions has been developed. Base-promoted selective cleavage of a C-C σ bond of the amide is the key in this process, which provides a straightf
Access to 2-Alkyl/Aryl-4-(1 H)-Quinolones via Orthogonal "nH3" Insertion into o-Haloaryl Ynones: Total Synthesis of Bioactive Pseudanes, Graveoline, Graveolinine, and Waltherione F
Mehta, Goverdhan,Nerella, Sharanya,Pabbaraja, Srihari,Singh, Shweta
, (2020/02/22)
An efficient one-pot synthesis of 4-(1H)-quinolones through an orthogonal engagement of diverse o-haloaryl ynones with ammonia in the presence of Cu(I), involving tandem Michael addition and ArCsp2-N coupling, is presented. The substrate scope of this convenient protocol, wherein ammonium carbonate acts as both an in situ ammonia source and a base toward diverse 2-substituted 4-(1H)-quinolones, has been mapped and its efficacy validated through concise total synthesis of bioactive natural products pseudanes (IV, VII, VIII, and XII), graveoline, graveolinine, and waltherione F.
Combining Electronic and Steric Effects to Generate Hindered Propargylic Alcohols in High Enantiomeric Excess
Vyas, Vijyesh K.,Knighton, Richard C.,Bhanage, Bhalchandra M.,Wills, Martin
, p. 975 - 978 (2018/02/23)
Tethered ruthenium-TsDPEN complexes have been applied to the catalysis of the asymmetric transfer hydrogenation of a range of aryl/acetylenic ketones. The introduction of an ortho- substituent to the aryl ring of the substrate results in a reversal of the
Nitromethane as a Carbanion Source for Domino Benzoannulation with Ynones: One-Pot Synthesis of Polyfunctional Naphthalenes and a Total Synthesis of Macarpine
Singh, Shweta,Samineni, Ramesh,Pabbaraja, Srihari,Mehta, Goverdhan
supporting information, p. 16847 - 16851 (2018/11/27)
A one-pot, transition-metal-free, domino Michael/SNAr protocol of general applicability has been devised for the regioselective synthesis of polyfunctional naphthalenes by employing nitromethane and ortho-haloaryl ynones. Utilization of nitromethane as a one carbon carbanion source that is incorporated into a variety of ynones, ends up as an aromatic nitro substituent. The application of this domino process towards a total synthesis of the polycyclic alkaloid macarpine demonstrate for the efficacy of this methodology. The conceptually simple approach to affect regioselective, multifunctional benzoannulation of ynones displays wide substrate scope and functional-group tolerance and has been implemented with substituted nitromethanes, as well as with alicyclic o-haloynones.
