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(4-(4-Aminopyridin-3-yl)phenyl)(piperidin-1-yl)methanone, also known as PHA-543613, is a small molecule compound that functions as a potent and selective agonist for the alpha-7 nicotinic acetylcholine receptor. This receptor plays a crucial role in cognitive function regulation and is associated with neurological disorders such as Alzheimer's disease and schizophrenia. PHA-543613's selective activation of the alpha-7 nicotinic acetylcholine receptor positions it as a promising candidate for drug development, with potential applications in enhancing cognitive function and treating neurodegenerative and inflammatory conditions.

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  • 1125414-05-2 Structure
  • Basic information

    1. Product Name: (4-(4-aMinopyridin-3-yl)phenyl)(piperidin-1-yl)Methanone
    2. Synonyms: (4-(4-aMinopyridin-3-yl)phenyl)(piperidin-1-yl)Methanone
    3. CAS NO:1125414-05-2
    4. Molecular Formula: C17H19N3O
    5. Molecular Weight: 281.35226
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1125414-05-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: 2-8°C
    8. Solubility: N/A
    9. CAS DataBase Reference: (4-(4-aMinopyridin-3-yl)phenyl)(piperidin-1-yl)Methanone(CAS DataBase Reference)
    10. NIST Chemistry Reference: (4-(4-aMinopyridin-3-yl)phenyl)(piperidin-1-yl)Methanone(1125414-05-2)
    11. EPA Substance Registry System: (4-(4-aMinopyridin-3-yl)phenyl)(piperidin-1-yl)Methanone(1125414-05-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1125414-05-2(Hazardous Substances Data)

1125414-05-2 Usage

Uses

Used in Pharmaceutical Industry:
PHA-543613 is used as a therapeutic agent for the treatment of neurological disorders such as Alzheimer's disease and schizophrenia. Its agonistic effect on the alpha-7 nicotinic acetylcholine receptor suggests its potential in modulating cognitive function and addressing the underlying mechanisms of these conditions.
Used in Drug Development Research:
In the field of drug development, PHA-543613 is utilized as a research compound to explore the role of the alpha-7 nicotinic acetylcholine receptor in cognitive function and neurodegenerative processes. This research aims to advance the understanding of receptor-targeted therapies and identify new treatment strategies for cognitive impairments and related disorders.
Used in Inflammatory and Autoimmune Disease Treatment:
PHA-543613 is also considered for use as a treatment for inflammatory and autoimmune diseases, given the receptor's involvement in immune system regulation. Its agonistic properties may contribute to the modulation of immune responses and provide therapeutic benefits in managing these conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 1125414-05-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,2,5,4,1 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1125414-05:
(9*1)+(8*1)+(7*2)+(6*5)+(5*4)+(4*1)+(3*4)+(2*0)+(1*5)=102
102 % 10 = 2
So 1125414-05-2 is a valid CAS Registry Number.

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