112545-69-4

Upstream product

• 63544-00-3 (2S,3R)-Oxirane-2,3-dicarboxylic acid monomethyl ester 
• 92685-83-1 N-<(tert-butoxycarbonyl)methyl>-p-anisidine 
• 56958-97-5 (2R,3S)-dimethyl oxirane-2,3-dicarboxylate 
• 63544-00-3 methyl (2RS,3SR)-2,3-oxiranedicarboxylate 

Downstream Products

• 114315-93-4 (2RS,3SR)-N-(t-butoxycarbonylmethyl)-N-(4-methoxyphenyl)-3-carboxy-2,3-epoxypropionamide 
• 114376-77-1 (3S,4S)-4-acetoxy-3-<(1R)-1-t-butyldimethylsilyloxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>-1-(4-methoxyphenyl)azetidin-2-one 
• 114315-97-8 (3R,4R)-4-acetoxy-3-<(1S)-1-t-butyldimethylsilyloxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>-1-(4-methoxyphenyl)azetidin-2-one 
• 116114-71-7 (2R,3S)-1-(t-butoxycarbonylmethyl)-1-(4-methoxyphenyl)-4-<(1S)-1-phenylethyl>-2,3-oxiranecarboxamide 
• 116114-71-7 (2S,3R)-1-(t-butoxycarbonylmethyl)-1-(4-methoxyphenyl)-4-<(1S)-1-phenylethyl>-2,3-oxiranecarboxamide 
• 114376-74-8 (3R,4R)-4-t-butoxycarbonyl-3-<(1R)-1-hydroxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>-1-(4-methoxyphenyl)azetidin-2-one 
• 114315-94-5 (3S,4S)-4-t-butoxycarbonyl-3-<(1S)-1-hydroxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>-1-(4-methoxyphenyl)azetidin-2-one 
• 114376-76-0 (3S,4S)-4-acetoxy-3-<(1R)-1-hydroxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>-1-(4-methoxyphenyl)azetidin-2-one 
• 114315-96-7 (3R,4R)-4-acetoxy-3-<(1S)-1-hydroxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>-1-(4-methoxyphenyl)azetidin-2-one 
• 114376-75-9 (3R,4R)-4-carboxy-3-<(1R)-1-hydroxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>-1-(4-methoxyphenyl)azetidin-2-one 
• 114315-95-6 (3S,4S)-4-carboxy-3-<(1S)-1-hydroxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>-1-(4-methoxyphenyl)azetidin-2-one 
• 114316-00-6 (3S,4S)-4-acetoxy-3-<(1R)-1-t-butyldimethylsilyloxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>azetidin-2-one 
• 114376-78-2 (3R,4R)-4-acetoxy-3-<(1S)-1-t-butyldimethylsilyloxymethyl-1-((1S)-1-phenylethylaminocarbonyl)>azetidin-2-one 
• 112545-71-8 [4-Hydroxy-1-(4-methoxy-phenyl)-2,5-dioxo-2,5-dihydro-1H-pyrrol-3-yl]-acetic acid tert-butyl ester 

Relevant academic research and scientific papers

Synthesis of an optically active 4-acetoxyazetidinone intermediate for penems and carbapenems

The synthesis of the novel (3R,4R)-4-acetoxy-3[(1S)-1-t-butyldimethylsilyloxymethyl-1-((1S)-1-ph nylethylaminocarbonyl)]azetidin-2-one, a valuable key intermediate for penems and carbapenems bearing a 6-hydroxyacetamide side chain, and its diastereomer 1b

SYNTHESIS OF A NEW CARBAPENEM WITH A 6-METHYL HYDROXYACETATE SIDE CHAIN

The synthesis of the 2-(4-pyridinylthio)-carbapen-2-em-3-carboxylic acid 1b, bearing a 6-methyl hydroxyacetate side chain, is decribed.