112545-96-7Relevant articles and documents
In Situ Generation of Alkynylzinc and Its Subsequent Negishi Reaction in a Flow Reactor
Kandasamy, Mohanraj,Huang, Yu- Hsuan,Ganesan, Balaji,Senadi, Gopal Chandru,Lin, Wei-Yu
, p. 4349 - 4356 (2019/07/03)
A highly efficient and convenient Negishi cross-coupling reaction has been developed for the synthesis of unsymmetrical alkynes and enynes in a continuous-flow process. The reaction proceeds through an in situ generated alkynylzinc reagent by the reaction of lithium acetylide with zinc halide at room temperature followed by a cross-coupling reaction with aryl or vinyl iodides. The notable features of this work compared to the conventional benchtop method are mild reaction conditions, good to excellent yields, broad functional-group compatibility, short residence time (73 sec) and especially desilylation of TMS group with the residence time of only 10.5 sec.
Splitting a Substrate into Three Parts: Gold-Catalyzed Nitrogenation of Alkynes by C-C and C≡C Bond Cleavage
Qin, Chong,Su, Yijin,Shen, Tao,Shi, Xiaodong,Jiao, Ning
supporting information, p. 350 - 354 (2016/01/25)
A gold-catalyzed nitrogenation of alkynes for the synthesis of carbamides and amino tetrazoles through C-C and C≡C bond cleavages is described. A diverse set of functionalized carbamide and amino tetrazole derivatives were selectively constructed under mild conditions. The chemoselectivity can be easily switched by the selection of the acid additives. The reaction is characterized by its broad substrate scope, direct construction of high value products, easy operation under air, and mild conditions at room temperature. This chemistry provides a way to transform alkynes by splitting the substrate into three parts.
Facile synthesis of substituted alkynes by nano-palladium catalyzed oxidative cross-coupling reaction of arylboronic acids with terminal alkynes
Nie, Xiaopeng,Liu, Suli,Zong, Yan,Sun, Peipei,Bao, Jianchun
experimental part, p. 1570 - 1573 (2011/06/17)
The oxidative cross-coupling of terminal alkynes with arylboronic acids catalyzed by the porous palladium nanospheres was developed. In the presence of silver oxide, triphenylphosphine and cesium carbonate, the reaction provided the corresponding arylalkynes with good to excellent yields. There were also other obvious advantages such as broad applicability, high selectivity, simple experimental operation as well as the convenient preparation, high efficiency and reusability of catalyst. The possible mechanism of this transition-metal nanoparticles catalyzed oxidative cross-coupling reaction of two nucleophiles was proposed.