112551-82-3

Usage

Molecular structure

composed of a piperazine ring, an ethanol group, a 2-chlorophenyl group, and a 1-naphthalenyloxymethyl group.

Functional groups

piperazine, ethanol, chlorophenyl, naphthalenyloxymethyl.

Therapeutic properties

potential serotonin antagonist, ability to block the reuptake of serotonin and norepinephrine.

Potential applications

treatment of various neurological and psychiatric disorders.

Need for further research

to fully understand its pharmacological effects and potential therapeutic uses.

Upstream product

• 2461-42-9 3-(1-naphthyloxy)-1,2-epoxypropane 
• 39512-50-0 N-(o-Chlorophenyl)piperazine 
• 90-15-3 α-naphthol 
• 41202-32-8 1-(2-chlorophenyl)piperazine hydrochloride 

Relevant academic research and scientific papers

New anticancer agent

PROBLEM TO BE SOLVED: To provide a compound having excellent anticancer activity equal to or greater than that of naftopidil.SOLUTION: This invention relates to a compound represented by formula (I), where the definition of each symbol is as described in

NOVEL ANTICANCER AGENT

The present invention aims to provide a compound having an anticancer action comparable or superior to that of naftopidil. A compound represented by the formula (I) wherein each symbol is as defined in the SPECIFICATION, or a pharmaceutically acceptable s

Synthesis, biological evaluation and mechanistic studies of totarol amino alcohol derivatives as potential antimalarial agents

Herein we report on the semisynthesis and biological evaluation of β-amino alcohol derivatives of the natural product totarol and other simple aromatic systems. All β-amino alcohol derivatives of totarol exhibited higher antiplasmodial activity than totarol [IC50: 11.69 μM (K1, chloroquine and multi-drug resistant strain), and 11.78 μM (D10, chloroquine sensitive strain)] - 12e was the most active [IC50: 0.63 μM (K1), and 0.61 μM (D10)]. The phenyl and naphthyl β-amino alcohol derivatives were much less active than their corresponding totarol equivalents. The majority of the β-amino alcohol derivatives of totarol were more active against K1 than the D10 strains of Plasmodium falciparum, a trend similar to the inverse relationship observed with the established aryl-amino alcohol antimalarial mefloquine. Selected compounds were shown to affect erythrocyte morphology, inhibit erythrocyte invasion and trigger CQ accumulation.

Complete assignments of 1H and 13C NMR data for ten phenylpiperazine derivatives

Ten phenylpiperazine derivatives were designed and synthesized. The first complete assignments of 1H and 13C NMR chemical shifts for these phenylpiperazine derivatives were achieved by means of 1D and 2D NMR techniques, including 1H-1H COSY, HSQC and HMBC spectra. Copyright