1125546-81-7Relevant academic research and scientific papers
5,5′- and 6,6′-Dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase
Ellis, David A.,Blazel, Julie K.,Tran, Chinh V.,Ruebsam, Frank,Murphy, Douglas E.,Li, Lian-Sheng,Zhao, Jingjing,Zhou, Yuefen,McGuire, Helen M.,Xiang, Alan X.,Webber, Stephen E.,Zhao, Qiang,Han, Qing,Kissinger, Charles R.,Lardy, Matthew,Gobbi, Alberto,Showalter, Richard E.,Shah, Amit M.,Tsan, Mei,Patel, Rupal A.,LeBrun, Laurie A.,Kamran, Ruhi,Bartkowski, Darian M.,Nolan, Thomas G.,Norris, Daniel A.,Sergeeva, Maria V.,Kirkovsky, Leo
scheme or table, p. 6047 - 6052 (2010/06/16)
The discovery of 5,5′- and 6,6′-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of the HCV RNA-dependent RNA polymerase (NS5B) is described. Several of these agents also display potent antiviral activity in cell culture experiments (EC50/
4-Hydroxy-5,6-dihydro-1H-pyridin-2-one compounds
-
Page/Page column 30, (2009/04/24)
The invention is directed to 4-hydroxy-5,6-dihydro-1H-pyridin-2-one compounds and pharmaceutical compositions containing such compounds that are useful in treating infections by hepatitis C virus.
