112561-89-4

Upstream product

• 87066-93-1 (2-Diethylamino-phenyl)-methanol 
• 615-36-1 2-bromoaniline 
• 1334232-88-0 2-bromo-N,N-dibutylaniline 
• 68-12-2 N,N-dimethyl-formamide 
• 111-92-2 dibutylamine 
• 446-52-6 2-Fluorobenzaldehyde 
• 728041-69-8 N-acetyl-N-ethyl-anthranilic acid ethyl ester 

Downstream Products

• 1453279-62-3 C₆₂H₇₆N₂ 
• 1453279-63-4 C₅₂H₅₈N₄ 
• 1453279-64-5 C₅₂H₅₈N₄ 
• 1453279-65-6 C₅₂H₅₈N₄ 
• 1453279-74-7 2,2'-((1E,1'E)-(2,5-diiodo-1,4-phenylene)bis(ethene-2,1-diyl))bis(N,N-dibutylaniline) 
• 112562-79-5 2-(2-Dibutylamino-phenyl)-thiazolidine-3-carbothioic acid methylamide; compound with sulfuric acid 

Relevant academic research and scientific papers

Development of TsDPEN based imine-containing ligands for the copper-catalysed asymmetric Kinugasa reaction

A novel class of chiralN,N,Nimine-containing ligands derived from TsDPEN (N-(p-tosyl)-1,2-diphenylethylene-1,2-diamine) has been developed and applied to the copper-catalyzed asymmetric Kinugasa reaction. The copper(ii) salt proved to be an efficient catalyst precursor, and it provides an efficient way to synthesize enantioenrichedcis-β-lactam. The pathway is air-tolerant and easily manipulated, and the ligands are easy to synthesize. A working model is proposed in which the stereocontrolling step is the [2 + 2] cycloaddition between ketene and imine to explain the observed stereoselectivities.

Investigation of the [1,5]-hydride shift as a route to nitro-Mannich cyclisations

Conditions were found for the [1,5]-hydride shift nitro-Mannich reaction that led to the synthesis of 2,3-disubstituted tetrahydroquinolines. Two simple cyclic amine substrates gave diastereomerically pure rearranged products in 65 and 90% yields by refluxing in HFIP. A more general procedure used Gd(OTf)3 as a catalyst and successfully rearranged other cyclic and acyclic amines in 42–84% yield with diastereomeric ratios of 75:25 to >95:5 in favour of the anti-diastereoisomer (9 examples). Two examples of sulphur containing heterocycles gave lower yields of 9 and 25%. Electron withdrawing substituents were shown to have a deleterious effect on the success of the reaction. The results indicated the limitation of the [1,5]-hydride shift nitro-Mannich reaction with respect to the stability of the intermediate iminium ion.

The photophysics of pyridine-derivatized ortho-, meta-, and para-dibutylamino cruciforms

The photophysical properties of a series of para-substituted donor-acceptor cruciform fluorophores (p1-4) were investigated and compared with their meta and ortho isomers (m1-4 and o1-4). The structural variations were found to have a significant effect o