1125632-93-0

Basic information

• Product Name: Takeda-6d
• Synonyms: Takeda-6d;2-Chloro-3-(1-cyanocyclopropyl)-N-[5-[[2-[(cyclopropylcarbonyl)aMino][1,3]thiazolo[5,4-b]pyridin-5-yl]oxy]-2-fluorophenyl]benzaMide
• CAS NO: 1125632-93-0
• Molecular Formula: C₂₇H₁₉ClFN₅O₃S
• Molecular Weight: 547.9878632
• Mol File: 1125632-93-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Takeda-6d(CAS DataBase Reference)
• NIST Chemistry Reference: Takeda-6d(1125632-93-0)
• EPA Substance Registry System: Takeda-6d(1125632-93-0)

Safety Data

• Hazardous Substances Data: 1125632-93-0(Hazardous Substances Data)

Usage

Uses

Used in Oncology:
Takeda-6d is used as an anti-cancer agent for its ability to target the JAK-STAT pathway and disrupt the MDM2-p53 interaction, leading to the inhibition of cancer cell proliferation and induction of apoptosis. It has demonstrated potent anti-cancer activity against various cancer cell lines, including those resistant to standard therapies.
Used in Drug Development for JAK-STAT Associated Diseases:
Takeda-6d is used as a potential therapeutic agent for the development of treatments for diseases associated with abnormal JAK-STAT signaling, due to its ability to selectively inhibit the JAK2 enzyme and modulate the MDM2-p53 interaction. Its promising results in preclinical studies suggest its potential in addressing unmet medical needs in the treatment of cancer and other related diseases.

Downstream Products

• 1220434-70-7 tert-butyl {[2-chloro-3-(1-cyanocyclopropyl)phenyl]carbonyl}[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]carbamate acetate 
• 1125634-69-6 tert-butyl {[2-chloro-3-(1-cyanocyclopropyl)phenyl]carbonyl}[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]carbamate 
• 1391975-68-0 C₃₂H₂₇ClFN₅O₅S 
• 1391975-70-4 C₃₇H₃₅ClFN₅O₇S 
• 1125634-71-0 2-chloro-3-(1-cyanocyclopropyl)-N-(cyclopropylcarbonyl)-N-[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]benzamide 
• 1125634-72-1 ethyl {[2-chloro-3-(1-cyanocyclopropyl)phenyl]carbonyl}[5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}oxy)-2-fluorophenyl]carbamate