1125702-46-6

Basic information

• Product Name: N-(2,3-Difluorophenyl)-3-oxobutanamide
• Synonyms: N-(2,3-difluorophenyl)-3-oxobutanamide
• CAS NO: 1125702-46-6
• Molecular Formula: C₁₀H₉F₂NO₂
• Molecular Weight: 213.18
• Mol File: 1125702-46-6.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: N-(2,3-Difluorophenyl)-3-oxobutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,3-Difluorophenyl)-3-oxobutanamide(1125702-46-6)
• EPA Substance Registry System: N-(2,3-Difluorophenyl)-3-oxobutanamide(1125702-46-6)

Safety Data

• Hazardous Substances Data: 1125702-46-6(Hazardous Substances Data)

Upstream product

• 4519-40-8 2,3-difluoroanilline 
• 105-45-3 acetoacetic acid methyl ester 

Downstream Products

• 953071-01-7 4-bromo-N-(2,3-difluorophenyl)-3-oxobutanamide 
• 1125862-04-5 4-(((3-chlorophenyl)(pyrimidin-5-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one 
• 1125861-48-4 4-(((3-chlorophenyl)(pyrimidin-2-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one 
• 1125861-60-0 4-(((3-chlorophenyl)(pyrazin-2-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one 
• 1125862-30-7 4-(((3-chlorophenyl)(pyrimidin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one 
• 1125862-26-1 4-(((3-chlorophenyl)(pyridazin-3-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one 
• 1125862-18-1 4-(((3-chlorophenyl)(pyridin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one 
• 1125868-26-9 4-(((3-chlorophenyl)(pyridin-3-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one 
• 1125861-56-4 4-(((3-chlorophenyl)(pyridin-2-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one 
• 1125862-66-9 4-(((3-chlorophenyl)(2-(dimethylamino)pyrimidin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one 
• 1125861-68-8 4-(((3-chlorophenyl)(phenyl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one 
• 1125861-70-2 4-(((3-chlorophenyl)(3-methylpyridin-2-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one 
• 1125862-40-9 4-(((3-chlorophenyl)(6-methylpyrimidin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one 
• 1125862-48-7 4-(((3-chlorophenyl)(2-methylpyrimidin-4-yl)amino)methyl)-7,8-difluoroquinolin-2(1H)-one 

Relevant articles and documents

Heteroaromatic-aminomethyl quinolones: Potent and selective iNOS inhibitors

The overproduction of nitric oxide during the biological response to inflammation by the nitric oxide synthase (NOS) enzymes have been implicated in the pathology of many diseases. By removal of the amide core from uHTS-derived quinolone 4, a new series highly potent heteroaromatic-aminomethyl quinolone iNOS inhibitors 8 were identified. SAR studies led to identification of piperazine 22 and pyrimidine 32, both of which reduced plasma nitrates following oral dosing in a mouse lipopolysaccharide challenge assay.

HETEROBICYCLIC-SUBSTITUTED QUINOLONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS

Novel Quinolone derivatives and pharmaceutical compositions, certain of which have been found to inhibit inducible NOS synthase have been discovered, together with methods of synthesizing and using the compounds including methods for the treatment of iNOS-mediated diseases in a patient by administering the compounds.

4- [HETEROCYCLYL-METHYL] -8-FLUORO-QUINOLIN-2-ONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS

Novel compounds of formulae (II, III) and pharmaceutical compositions have been found to inhibit inducible NOS synthase wherein: R4, R5, R6 and R7 are independently selected from the group consisting of hydrogen, lower alkyl, and halogen; and, R8 has the structure whrein X1, X2, X3, X4, X5, X6, R9, R13, R14 and n are as described herein.