112579-43-8Relevant articles and documents
Diversity-Oriented Synthesis of Natural-Product-like Libraries Containing a 3-Methylbenzofuran Moiety for the Discovery of New Chemical Elicitors
He, Xingrui,Chen, Xia,Lin, Songbo,Mo, Xiaochang,Zhou, Pengyong,Zhang, Zhihao,Lu, Yaoyao,Yang, Yu,Gu, Haining,Shang, Zhicai,Lou, Yonggen,Wu, Jun
, p. 102 - 111 (2017/02/10)
Natural products are a major source of biological molecules. The 3-methylfuran scaffold is found in a variety of plant secondary metabolite chemical elicitors that confer host-plant resistance against insect pests. Herein, the diversity-oriented synthesis of a natural-product-like library is reported, in which the 3-methylfuran core is fused in an angular attachment to six common natural product scaffolds—coumarin, chalcone, flavone, flavonol, isoflavone and isoquinolinone. The structural diversity of this library is assessed computationally using cheminformatic analysis. Phenotypic high-throughput screening of β-glucuronidase activity uncovers several hits. Further in vivo screening confirms that these hits can induce resistance in rice to nymphs of the brown planthopper Nilaparvata lugens. This work validates the combination of diversity-oriented synthesis and high-throughput screening of β-glucuronidase activity as a strategy for discovering new chemical elicitors.
Benzofuran fluoroflavanone derivative and preparation method thereof
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Paragraph 0050-0055, (2017/07/21)
The present invention relates to the field of pharmaceutical chemistry. A purpose of the present invention is to provide a benzofuran fluoroflavanone derivative and a preparation method thereof, wherein the product has a structure represented by a formula (I), the ring B is selected from phenyl or furyl, and R1, R2 and R3 are independently and respectively selected from hydrogen atom, halogen, cyano, nitro, a C1-C7 alkyl chain and C1-C7 alkoxy. According to the present invention, the benzofuran fluoroflavanone derivative is a class of the benzofuran flavone analogs having the new skeleton, and has potential pharmacological activity; the preparation of the compound can provide the support for the research of the pharmacological activity of the benzofuran flavone; and the preparation method has advantages of simple step and low loss rate, is the completely-new benzofuran flavone derivative synthesis route from the non-aromatic raw material, and provides important significance for the industrial production. The formula (I) is defined in the specification.
Substituted furan isoflavone derivatives and its preparation method (by machine translation)
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Page/Page column 9, (2017/08/27)
The present invention relates to the field of medicinal chemistry, and aims to provide a substituted furan isoflavone derivatives and its preparation method. The substituted furan isoflavone derivatives of formula (I) has the structure as illustrated, wherein R1 , R2 Each independently selected from hydrogen atom, methyl, methoxy or halogen. The product is a kind of has a new skeleton of natural furan isoflavone analogs, with potential pharmaceutical activity, the compounds of preparation can be furyl isoflavone pharmaceutical active research provide support; its preparation method step is simple, low loss rate. For the industrial production of important significance. (by machine translation)
