1125828-44-5

Basic information

• Product Name: (S)-ethyl 3-(4-(2-aMino-6-((R)-1-(4-chloro-2-(3-Methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyriMidin-4-yl)phenyl)-2-(tert-butoxycarbonylaMino)propanoate
• Synonyms: (S)-ethyl 3-(4-(2-aMino-6-((R)-1-(4-chloro-2-(3-Methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyriMidin-4-yl)phenyl)-2-(tert-butoxycarbonylaMino)propanoate;L-Phenylalanine, 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-N-[(1,1-dimethylethoxy)carbonyl]-, ethyl ester;ethyl (S)-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)-2-((tert-butoxycarbonyl)amino)propanoate;4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-N-[(1,1-dimethylethoxy)carbonyl]-L-Phenylalanine ethyl ester;(S)-ethyl 3-(4-(2-aMino-6-((R)-1-(4-chloro-2-(3-Methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyriMidin-4-yl)phenyl)-2-(tert-butoxycarbonylaMin
• CAS NO: 1125828-44-5
• Molecular Formula: C₃₂H₃₄ClF₃N₆O₅
• Molecular Weight: 675.0977696
• EINECS: -0
• Mol File: 1125828-44-5.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (S)-ethyl 3-(4-(2-aMino-6-((R)-1-(4-chloro-2-(3-Methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyriMidin-4-yl)phenyl)-2-(tert-butoxycarbonylaMino)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-ethyl 3-(4-(2-aMino-6-((R)-1-(4-chloro-2-(3-Methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyriMidin-4-yl)phenyl)-2-(tert-butoxycarbonylaMino)propanoate(1125828-44-5)
• EPA Substance Registry System: (S)-ethyl 3-(4-(2-aMino-6-((R)-1-(4-chloro-2-(3-Methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyriMidin-4-yl)phenyl)-2-(tert-butoxycarbonylaMino)propanoate(1125828-44-5)

Safety Data

• Hazardous Substances Data: 1125828-44-5(Hazardous Substances Data)

Usage

General Description

"(S)-ethyl 3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)-2-(tert-butoxycarbonylamino)propanoate, also known as TAK-788, is a chemical compound with potential anti-cancer properties. It is an inhibitor of epidermal growth factor receptor (EGFR) and human EGFR 2 (HER2). TAK-788 has shown promise in preclinical studies for the treatment of non-small cell lung cancer (NSCLC) and other solid tumor malignancies that harbor EGFR and HER2 mutations. Its unique structure and specific mechanism of action make it a potential candidate for targeted cancer therapy, and it is currently being evaluated in clinical trials for its efficacy and safety in cancer treatment."

Upstream product

• 64-17-5 ethanol 
• 1033805-27-4 (S)-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)-2-(tert-butoxycarbonylamino)propanoic acid 

Downstream Products

• 1033805-22-9 (2S)-2-amino-3-[4-[2-amino-6-[[(1R)-1-[4-chloro-2-(3-methylpyrazol-1-yl)phenyl]-2,2,2-trifluoroethyl]oxy]pyrimidin-4-yl]phenyl]propionic acid ethyl ester 

Relevant articles and documents

METHODS OF PREPARING 4-PHENYL-6-(2,2,2-TRIFLUORO-1-PHENYLETHOXY)PYRIMIDINE-BASED COMPOUNDS

Methods useful for preparing compounds of formula I: and salts thereof are disclosed. Also disclosed are intermediates useful in the preparation of such compounds.