112607-27-9

Basic information

• Product Name: 2(3H)-Furanone, dihydro-3-phenyl-, (3R)-
• CAS NO: 112607-27-9
• Molecular Formula: C10H10O2
• Molecular Weight: 162.188
• Mol File: 112607-27-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2(3H)-Furanone, dihydro-3-phenyl-, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(3H)-Furanone, dihydro-3-phenyl-, (3R)-(112607-27-9)
• EPA Substance Registry System: 2(3H)-Furanone, dihydro-3-phenyl-, (3R)-(112607-27-9)

Safety Data

• Hazardous Substances Data: 112607-27-9(Hazardous Substances Data)

Upstream product

• 66661-69-6 2-Phenylmaleinaldehydsaeure-ethylester 
• 51425-66-2 (4,5-dihydro-2-furanyloxy)(trimethyl)silane 
• 17763-67-6 Phenyl triflate 
• 879098-62-1 (2R,3R)-2-{(+)-isomenthoxy}-3-phenyl-1-oxacyclopentane 
• 121925-53-9 4-ethoxy-4-oxo-2-phenylbutanoic acid 
• 6836-98-2 3-phenyldihydrofuran-2-one 
• 1131-15-3 2-phenylsuccinic anhydride 

Downstream Products

• 6837-05-4 (+/-)-2-phenyl-1,4-butanediol 

Relevant articles and documents

Catalytic, Enantioselective β-Protonation through a Cooperative Activation Strategy

The NHC-catalyzed transformation of unsaturated aldehydes into saturated esters through an organocatalytic homoenolate process has been thoroughly studied. Leveraging a unique “Umpolung”-mediated β-protonation, this process has evolved from a test bed for homoenolate reactivity to a broader platform for asymmetric catalysis. Inspired by our success in using the β-protonation process to generate enals from ynals with good E/Z selectivity, our early studies found that an asymmetric variation of this reaction was not only feasible, but also adaptable to a kinetic resolution of secondary alcohols through NHC-catalyzed acylation. In-depth analysis of this process determined that careful catalyst and solvent pairing is critical for optimal yield and selectivity; proper choice of nonpolar solvent provided improved yield through suppression of an oxidative side reaction, while employment of a cooperative catalytic approach through inclusion of a hydrogen bond donor cocatalyst significantly improved enantioselectivity.

Enantioselective β-Protonation by a Cooperative Catalysis Strategy

An enantioselective N-heterocyclic carbene (NHC)-catalyzed β-protonation through the orchestration of three distinct organocatalysts has been developed. This cooperative catalyst system enhances both yield and selectivity, compared to only the NHC-catalyz

Catalytic hydrogenation of carboxamides and esters by well-defined Cp*Ru complexes bearing a protic amine ligand

A novel catalytic method for the straightforward hydrogenation of carboxamides and esters to primary alcohols has been developed. Chiral modification in the ligand sphere of the well-defined Cp*Ru catalyst molecule opens up a new possibility for the development of an enantioselective hydrogenation of racemic substrates via dynamic kinetic resolution.