112622-60-3Relevant academic research and scientific papers
Synthesis and Reactivity of Some Amino-Substituted 1,2,5-Thiadiazole 1,1-Dioxides
Aran, Vicente J.,Ruiz, Jose R.,Davila, Elena,Alkorta, Ibon,Stud, Manfred
, p. 337 - 342 (2007/10/02)
The acid-catalyzed cyclizing addition of sulfamide to cyanogen yielded 3,4-diamino-1,2,5-thiadiazole 1,1-dioxide (2), from which through amino-exchange reactions, the substituted compounds 3, 4, and 5 could be derived.The unsubstituted amino groups of compounds 2 and 3 were easily hydrolysed by basic treatment; the former afforded the 4-amino-3-oxothiadiazole 8 or the dipotassium salt 6 depending on the conditions, and the latter, 4-amino-3-oxo-1,2,5-thiadiazoles 1.Alternative syntheses of compounds 1a,b and 8 by hydrogenolysis of the corresponding 2-benzyl derivatives are also reported.
