112632-95-8

Basic information

• Product Name: (E)-2-(benzo[d]thiazol-2-yl)-3-(2-methoxyphenyl)acrylonitrile
• Synonyms: (E)-2-(benzo[d]thiazol-2-yl)-3-(2-methoxyphenyl)acrylonitrile;(E)-2-(1,3-benzothiazol-2-yl)-3-(2-methoxyphenyl)prop-2-enenitrile
• CAS NO: 112632-95-8
• Molecular Formula: C17H12N2OS
• Molecular Weight: 292.35498
• Mol File: 112632-95-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (E)-2-(benzo[d]thiazol-2-yl)-3-(2-methoxyphenyl)acrylonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-2-(benzo[d]thiazol-2-yl)-3-(2-methoxyphenyl)acrylonitrile(112632-95-8)
• EPA Substance Registry System: (E)-2-(benzo[d]thiazol-2-yl)-3-(2-methoxyphenyl)acrylonitrile(112632-95-8)

Safety Data

• Hazardous Substances Data: 112632-95-8(Hazardous Substances Data)

Usage

General Description

(E)-2-(benzo[d]thiazol-2-yl)-3-(2-methoxyphenyl)acrylonitrile is a chemical compound with a molecular formula of C20H14N2OS. It is a nitrile derivative with a benzothiazole ring and a methoxyphenyl group attached to an acrylonitrile moiety. (E)-2-(benzo[d]thiazol-2-yl)-3-(2-methoxyphenyl)acrylonitrile is a yellow crystalline solid that is commonly used as a fluorescent dye for imaging biological materials. It has also been studied for its potential use as a sensor for detecting metal ions. In addition, it has shown promising anti-tumor activity in certain cancer cell lines, making it a potential candidate for further pharmaceutical research and drug development.

Upstream product

• 56278-50-3 2-cyanomethylbenzothiazole 
• 135-02-4 ortho-anisaldehyde 

Relevant articles and documents

Magnetic nanoparticle supported amine: An efficient and environmental benign catalyst for versatile Knoevenagel condensation under ultrasound irradiation

Amine functionalized silica coated Fe3O4 nanoparticles (SiO2@MNP-A) were successfully prepared as a novel heterogeneous amine. The catalyst was characterized by XRD, FT-IR, TEM, magnetic measurement, elemental analysis and was found to be a magnetically separable and highly active catalyst for ambient Knoevenagel condensation of aromatic aldehydes and a-aromatic (heteroaromatic or polyaromatic)-substituted methylene compounds in water under ultrasonic irradiation to afford the corresponding products in good to excellent yields. Very interestingly, SiO2@MNP-A successfully catalyze the reaction of the non-cyano substituted compound with benzaldehyde to achieve a key intermediate for the preparation of Atorvastatin calcium in green and atom-economic manner. In addition, the catalyst SiO2@MNP-A can be reused for 8 times without any obvious loss of its activity. The role of ultrasonication in the Knoevenagel condensation was also discussed with the assistance of UV-vis spectrometry.

SYNTHESIS AND STRUCTURE ELUCIDATION OF BENZOTHIAZOLE-CONTAINING COMPOUNDS FOR ANTIMICROBIAL INVESTIGATION

Attempted cycloaddition of benzimidazole-2-thiol with arylidenemalononitriles 1 was unsuccessful. 2-Cyanomethyl-1,3-benzothiazole 6 condensed with certain aromatic aldehydes to produce 7, cycloaddition of which with cyanoacethydrazide 3 yielded 8. Structu