112633-39-3Relevant academic research and scientific papers
New tricks of well-known aminoazoles in isocyanide-based multicomponent reactions and antibacterial activity of the compounds synthesized
Murlykina, Maryna V.,Kornet, Maryna N.,Desenko, Sergey M.,Shishkina, Svetlana V.,Shishkin, Oleg V.,Brazhko, Aleksander A.,Musatov, Vladimir I.,Van Der Eycken, Erik V.,Chebanov, Valentin A.
, p. 1050 - 1063 (2017)
The well-known aminoazoles, 3-amino-5-methylisoxazole and 5-amino-N-aryl-1H-pyrazole-4-carboxamides, were studied as an amine component in Ugi and Groebke-Blackburn-Bienaymé multicomponent reactions. The first example of an application of aminoazoles in an Ugi four-component reaction was discovered and novel features of a Groebke-Blackburn-Bienaymé cyclocondensation are established and discussed. The heterocycles obtained were evaluated for their antibacterial activity and several of them demonstrated a weak antimicrobial effect, but for most of the compounds a 30-50% increase in biomass of Gram-positive strains (mainly B. subtilis) compared to control was observed.
Unusual products of reaction between aminoisoxazoles and aromatic aldehydes
Duran, Burcu,Ko?odziej, Beata,Morawiak, Maja,Schilf, Wojciech
, (2021/09/20)
The reaction between primary amine and aldehyde usually leads to a Schiff base. In this work, we present the results of research (NMR, ATR-FTIR, UV–Vis, and X-ray) of products obtained in the reaction of 5-methyl-3-aminoisoxazole (3AMI) or 3-methyl-5-amin
Isoxazole derivatives as potent transient receptor potential melastatin type 8 (TRPM8) agonists
Ostacolo, Carmine,Ambrosino, Paolo,Russo, Roberto,Lo Monte, Matteo,Soldovieri, Maria Virginia,Laneri, Sonia,Sacchi, Antonia,Vistoli, Giulio,Taglialatela, Maurizio,Calignano, Antonio
, p. 659 - 669 (2013/10/22)
Modulation of the transient receptor potential melastatin type-8 (TRPM8), the receptor for menthol acting as the major sensor for peripheral innocuous cool temperatures, has several important applications in pharmaceutical, food and cosmetic industries. I
Synthesis and antidiabetic performance of β-amino ketone containing nabumetone moiety
Wang, Hang,Yan, Ju-Fang,Song, Xiao-Li,Fan, Li,Xu, Jin,Zhou, Guang-Ming,Jiang, Li,Yang, Da-Cheng
experimental part, p. 2119 - 2130 (2012/05/05)
We wish to report the further design and improved synthesis that resulted in two series of target molecules, TM-1 and TM-2, with remarkably simplified structures containing β-amino ketone of discrete nabumetone moiety. These were obtained via a 'one-pot,
Synthesis of isoxazolyl oxadiazolines and thiazolidinones
Rajanarendar,Afzal,Ramu
, p. 927 - 930 (2007/10/03)
4-(5-Methyl-3-isoxazolyl)-3,5-diaryl-Δ2-1,2,4-oxadiazolines have been prepared by benzonitrile oxide addition to 3-benzalamino-5-methyl isoxazoles. The Schiff bases have been obtained by the condensation of aromatic aldehydes with 3-amino-5-met
