112633-39-3

Basic information

• Product Name: 3-Isoxazolamine, 5-methyl-N-[(4-nitrophenyl)methylene]-
• CAS NO: 112633-39-3
• Molecular Formula: C11H9N3O3
• Molecular Weight: 231.211
• Mol File: 112633-39-3.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-Isoxazolamine, 5-methyl-N-[(4-nitrophenyl)methylene]-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Isoxazolamine, 5-methyl-N-[(4-nitrophenyl)methylene]-(112633-39-3)
• EPA Substance Registry System: 3-Isoxazolamine, 5-methyl-N-[(4-nitrophenyl)methylene]-(112633-39-3)

Safety Data

• Hazardous Substances Data: 112633-39-3(Hazardous Substances Data)

Usage

Derivative of

Isoxazole

Functional Groups

Contains a nitrophenyl group

Potential Pharmacological Applications

Antimicrobial Activity: Due to its isoxazole and nitrophenyl moieties
Antitumor Activity: Linked to its structural features

Potential Uses

Drug Development: May contribute to the synthesis of new drugs
Agricultural Pesticides: Possible application in agricultural sectors

Safety Considerations

Caution Required: Handle with care and adhere to safety protocols
Health Hazards: Potential health risks associated with handling

Upstream product

• 1072-67-9 5-methylisoxazol-3-ylamine 
• 555-16-8 4-nitrobenzaldehdye 

Downstream Products

• 1295478-23-7 C₁₉H₁₅N₅O₄S 
• 1295478-11-3 C₁₂H₁₀N₄O₃S 
• 1206182-25-3 5-(6-methoxynaphthalen-2-yl)-1-(5-methylisoxazol-3-ylamino)-1-(4-nitrophenyl)pentan-3-one 

Relevant articles and documents

New tricks of well-known aminoazoles in isocyanide-based multicomponent reactions and antibacterial activity of the compounds synthesized

The well-known aminoazoles, 3-amino-5-methylisoxazole and 5-amino-N-aryl-1H-pyrazole-4-carboxamides, were studied as an amine component in Ugi and Groebke-Blackburn-Bienaymé multicomponent reactions. The first example of an application of aminoazoles in an Ugi four-component reaction was discovered and novel features of a Groebke-Blackburn-Bienaymé cyclocondensation are established and discussed. The heterocycles obtained were evaluated for their antibacterial activity and several of them demonstrated a weak antimicrobial effect, but for most of the compounds a 30-50% increase in biomass of Gram-positive strains (mainly B. subtilis) compared to control was observed.

Isoxazole derivatives as potent transient receptor potential melastatin type 8 (TRPM8) agonists

Modulation of the transient receptor potential melastatin type-8 (TRPM8), the receptor for menthol acting as the major sensor for peripheral innocuous cool temperatures, has several important applications in pharmaceutical, food and cosmetic industries. I

Synthesis of isoxazolyl oxadiazolines and thiazolidinones

4-(5-Methyl-3-isoxazolyl)-3,5-diaryl-Δ2-1,2,4-oxadiazolines have been prepared by benzonitrile oxide addition to 3-benzalamino-5-methyl isoxazoles. The Schiff bases have been obtained by the condensation of aromatic aldehydes with 3-amino-5-met