1126431-84-2

Upstream product

• 13036-02-7 Dimethyl 5-hydroxyisophthalate 
• 618-83-7 5-Hydroxyisophthalic acid 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 367519-84-4 3-hydroxymethyl-5-methoxy-benzoic acid methyl ester 
• 20319-44-2 dimethyl 5-methoxyisophthalate 

Downstream Products

• 1126431-85-3 2-(2-chloro-4-pyrimidinyl)-1-[3-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-5-(methyloxy)phenyl]ethanone 
• 913602-79-6 1-(2,2-dimethyl-propionyloxymethyl)-3-methoxy-5-methyl-cyclohexa-2,5-dienecarboxylic acid methyl ester 
• 1410799-74-4 C₂₂H₃₈O₆Si 
• 1410799-83-5 C₁₇H₃₀O₄Si 
• 1410799-84-6 methyl 5-methoxy-1,3-dimethyl-2,5-cyclohexadiene-1-carboxylate 

Relevant academic research and scientific papers

Birch Reductive Alkylation of Methyl m-(Hydroxymethyl)benzoate Derivatives and the Behavior of o- and p-(Hydroxymethyl)benzoates under Reductive Alkylation Conditions

Birch reductive alkylation of methyl m-(hydroxymethyl)benzoate derivatives, using lithium in ammonia-tetrahydrofuran in the presence of tertbutyl alcohol, can be achieved without significant loss of benzylic oxygen substituents. Similar treatment of o- and p-(hydroxymethyl)benzoate derivatives results largely in loss of benzylic oxygen substituents. The results are rationalized by computations describing electron density patterns in the putative radical anion intermediate involved in these reactions.

THIAZOLE AND OXAZOLE KINASE INHIBITORS

The present invention provides thiazole and oxazole compounds, compositions containing the same, as well as processes for the preparation and methods for their use as pharmaceutical agents.