1126527-86-3Relevant academic research and scientific papers
A convenient and facile synthesis of new thiazole derivatives
El Rady, Eman A.
experimental part, p. 1659 - 1671 (2009/08/07)
4-Chloro-2,3-dihydrothiazole-5-carboxaldehyde reacted with some nucleophilic reagents such as hydrazine hydrate, phenyl hydrazine, urea, thiourea, semicarbazide, cyanoacetamide, cyanothio-acetamide, cyanoacetohydrazide, 2-phenylenediamine, 2-aminophenol, 5-amino[1,2,4]triazole and 3-aminopyrazole in ethanol solution at reflux in the presence of catalytic amount of triethyl-amine afforded new polysubstituted thiazolo[4,5-c]pyrazole, thiazolo[4,5-d]-pyrimidine, thiazolo[4,5-b]-pyridine, thiazolo[4,5-b][1,5] benzodiazepine, thiazolo[4,5-b] [1,5]benzoxazepine, thiazolo[4′, 5′:6,5]-pyrimido[1,2-b][1,2,4]triazole and thiazolo[4′, 5′:6,5]pyrimido[1,2-b]pyrazole derivatives in good yields. The structure of the new compounds were confirmed based on IR, 1 H-,13C-NMR, mass spectral, and elemental analysis. Copyright Taylor & Francis Group, LLC.
