1126635-53-7

Upstream product

• 613-94-5 benzoic acid hydrazide 
• 2900-27-8 2-(tert-butoxycarbonylamino)-2-phenylacetic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1227858-22-1 N-Boc-2-phenylglycine N'-(α-ethoxybenzylidene)hydrazide 
• 1126635-30-0 N-[1-phenyl-1-(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]acetamide 
• 1126635-26-4 tert-butyl N-[(R)-phenyl(hydrazinecarbonyl)methyl]carbamate 
• 1663-61-2 triethoxymethylbenzene 
• 1043912-48-6 L-(+)-N-BOC-phenylglycine hydrazide 
• 2900-27-8 (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid 

Downstream Products

• 1126635-57-1 2-(1-amino-1-phenylmethyl)-5-phenyl-1,3,4-oxadiazole hydrochloride 
• 1126635-45-7 1-(5-phenyl-1,3,4-oxadiazol-2-yl)-1-phenylmethylammonium trifluoromethanesulfonate 
• 1126635-30-0 N-[1-phenyl-1-(5-phenyl-1,3,4-oxadiazol-2-yl)methyl]acetamide 
• 1029736-28-4 2-phenyl-N-(phenyl-(5-phenyl-1,3,4-oxadiazol-2-yl)methyl)acetamide 
• 1017206-29-9 2-(1-amino-1-phenylmethyl)-5-phenyl-1,3,4-oxadiazole 

Relevant academic research and scientific papers

Discovery of small molecules that enhance astrocyte differentiation in rat fetal neural stem cells

1,3,4-Oxadiazole derivatives were found to enhance astrocyte differentiation in rat fetal neural stem cells (NSCs). Differentiation activity was assessed by immunocytochemistry and analysis of mRNA expression of astrocyte markers, GFAP and S100. Compounds 7 and 8 showed approximately a two-fold increase in astrocyte differentiation without engagement of neuronal differentiation and detectable cytotoxicity.

N-protected N2-ethoxymethylene phenylglycine hydrazides as precursors of 1,3,4-oxadiazole derivatives

New derivatives of N2-ethoxymethylene phenylglycine hydrazide protected at the amino group by acetyl and tert-butoxycarbonyl were synthesized with reactions of N-protected phenylglycine hydrazides andtriethyl orthoesters. They underwent cycliza

An efficient synthesis of new 2-aminomethyl-1,3,4-oxadiazoles from enantiomeric phenylglycine hydrazides

New derivatives of 2-aminomethyl-1,3,4-oxadiazole were synthesized in the reactions of N-protected phenylglycine hydrazides and triethyl orthoesters (orthoformate, orthoacetate, orthopropionate, orthobenzoate) in the presence of glacial acetic acid. Studies on the cleavage reactions of the acid-sensitive N-BOC and N-Ac 1,3,4-oxadiazoles are presented. Spectral characteristics of the compounds and attempts to elucidate the racemization phenomenon observed in products are also discussed.

A mild and efficient one pot synthesis of 1,3,4-oxadiazoles from carboxylic acids and acyl hydrazides

A convenient one pot method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from acids and acyl hydrazides is reported. Acid activation with CDI, followed by coupling with the desired acylhydrazide and dehydration in the same pot with Ph3P and CBr4 affords the corresponding 1,3,4-oxadiazoles in good yield. The scope of the acid and acylhydrazide components is presented.