1126639-29-9Relevant academic research and scientific papers
A novel and convenient synthesis of cyclopent-1-enecarboxylates by an intramolecular Horner-Wadsworth-Emmons reaction
Krawczyk, Henryk,Albrecht, Lukasz
experimental part, p. 3951 - 3956 (2009/06/05)
A general and efficient method for the preparation of 2-diethoxyphosphoryl- 6-oxohexanoates is presented. This approach is based on the Michael addition of [2-(1,3-dioxolan-2-yl)ethyl]magnesium bromide to various 3-substituted tert-butyl (E)-2-(diethoxyphosphoryl)alk-2-enoates as a key step. Application of the 2-diethoxyphosphoryl-6-oxohexanoates obtained in the intramolecular Horner-Wadsworth-Emmons reaction for the preparation of 5-substituted tert-butyl cyclopent-1-enecarboxylates is also reported. Georg Thieme Verlag Stuttgart.
