112670-47-0

Basic information

• Product Name: 4-(2-TERT-BUTOXYCARBONYLAMINO-3-PHENYL-PROPIONYLAMINO)-BUTYRIC ACID
• Synonyms: 4-(2-((tert-Butoxycarbonyl)aMino)-3-phenylpropanaMido)butanoic acid
• CAS NO: 112670-47-0
• Molecular Formula: C₁₈H₂₆N₂O₅
• Molecular Weight: 350.41
• Mol File: 112670-47-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 614°Cat760mmHg
• Flash Point: 325.1°C
• Appearance: /
• Density: 1.165g/cm³
• Vapor Pressure: 6.25E-16mmHg at 25°C
• CAS DataBase Reference: 4-(2-TERT-BUTOXYCARBONYLAMINO-3-PHENYL-PROPIONYLAMINO)-BUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-TERT-BUTOXYCARBONYLAMINO-3-PHENYL-PROPIONYLAMINO)-BUTYRIC ACID(112670-47-0)
• EPA Substance Registry System: 4-(2-TERT-BUTOXYCARBONYLAMINO-3-PHENYL-PROPIONYLAMINO)-BUTYRIC ACID(112670-47-0)

Safety Data

• Hazardous Substances Data: 112670-47-0(Hazardous Substances Data)

Usage

InChI:InChI=1/C18H26N2O5/c1-18(2,3)25-17(24)20-14(12-13-8-5-4-6-9-13)16(23)19-11-7-10-15(21)22/h4-6,8-9,14H,7,10-12H2,1-3H3,(H,19,23)(H,20,24)(H,21,22)/p-1/t14-/m1/s1

Upstream product

• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 1417603-49-6 C₃₄H₄₃N₃O₇ 
• 1417603-53-2 C₃₅H₄₅N₃O₇ 
• 1417603-45-2 (S)-tert-butyl 1-[3-(3-methyl-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-propylamino]-1-oxo-3-phenylpropan-2-ylcarbamate 
• 136630-69-8 BOC-Phe-N-(CH2)3CO-ACHPA-Ile N-<(4-amino-2-methyl-5-pyrimidinyl)methyl>amide 

Relevant articles and documents

Prodrugs of compounds that enhance antifungal activity and compositions of said prodrugs

The invention relates to prodrugs for use in the inhibition of histone deacetylase. The prodrugs of the present invention have good aqueous solubility and good aqueous stability. The prodrugs of the invention advantageously are metabolized to the active i

Direct C-H alkylation of naphthoquinones with amino acids through a revisited Kochi-Anderson radical decarboxylation: Trends in reactivity and applications

In our ongoing research program into the discovery of new anticancer drugs, we were interested in the preparation of naphthoquinone scaffolds bearing aminoalkyl side-chains. Following this aim, we revisited the Kochi-Anderson radical decarboxylation of amino acids in order to set up a versatile route to the direct functionalization of naphthoquinones. The best reaction conditions were applied to a selected series of compounds in a systematic methodological study which allowed us to establish important trends in reactivity. We found that α-substituted β-amino acids were the most suitable substrates for the radical addition. In contrast, α-amino acids gave modest results. The influence of the amine protecting groups on the reaction outcome has also been studied. This practical procedure allows the introduction of various unsymmetrical moieties, including orthogonally protected linear aminoalkyl chains or chiral dipeptidic chains, and opens the door to a wide scope of easily accessible chemical diversity.