112677-05-1Relevant articles and documents
[2+2] Cycloaddition of electron-poor acetylenes to (E)-3-dimethylamino-1-heteroaryl-prop-2-en-1-ones: synthesis of highly functionalized 1-heteroaroyl-1,3-butadienes
Bezen?ek, Jure,Kole?a, Tanja,Gro?elj, Uro?,Wagger, Jernej,Stare, Katarina,Meden, Anton,Svete, Jurij,Stanovnik, Branko
, p. 3392 - 3397 (2010)
Microwave-assisted [2+2] cycloaddition of (E)-3-dimethylamino-1-heteroaryl-prop-2-en-1-ones to dimethyl acetylenedicarboxylates gives (2E,3E)-dimethyl-2-[(dimethylamino)methylene]-3-(substituted)succinates in 8-91% yield. In the case of a 4,5-dihydrothiazoline derivative, cycloaddition also took place at the endocyclic C{double bond, long}N double bond.
Design, synthesis, and preliminary bioactivity evaluation of N-benzylpyrimidin-2-amine derivatives as novel histone deacetylase inhibitor
Zhou, Yi,Dun, Yanyan,Fu, Huansheng,Wang, Lei,Pan, Xiaole,Yang, Xinying,Fang, Hao
, p. 936 - 942 (2017/10/05)
Histone deacetylase (HDAC) inhibitors have been identified for the treatment of cancer. Lately, we designed and synthesized a series of substituted N-benzylpyrimidin-2-amine derivatives as potent HDAC inhibitors. In vitro HDAC inhibitory activities and an
First examples of 2,6-diarylnicotinaldehydes prepared under conventional and microwave conditions
Shankaraiah,Chandrasekhar,Siva Nagi Reddy,Sabitha, Gowravaram
, p. 842 - 846 (2015/03/04)
Enaminoketones undergo unexpected self condensation in acetic acid to produce a wide range of 2,3,6-trisubstituted pyridine derivatives in excellent yields in the presence of NH4OAc. This is the first Letter on the synthesis of 2,6-diarylnicoti
