112678-34-9Relevant academic research and scientific papers
Preparation of Perfluoroalkyl Ketones by the Reaction of Perfluoroalkyllithiums with Esters
Uno, Hidemitsu,Shiraishi, Yasukazu,Suzuki, Hitomi
, p. 2636 - 2642 (2007/10/02)
A variety of esters react with perfluoroalkyllithiums in situ generated from perfluoroalkyl iodides and methyllithium to give perfluoroalkyl ketones in good yields.Perfluoroalkyllithiums add to α,β-unsaturated esters only in the 1,2-addition mode even in the presence of copper salt.Exception was observed in the reaction with maleates where perfluoroalkylated succinic esters and normal 1,2-addition products are obtained in comparable amounts.
An Efficient Synthesis of Perfluoroalkyl Ketones Using Perfluoroalkyllithiums
Uno, Hidemitsu,Shiraishi, Yasukazu,Simokawa, Kazuhiro,Suzuki, Hitomi
, p. 1153 - 1156 (2007/10/02)
Perfluoroalkylation of esters with perfluoroalkyllithiums occurs smoothly in ether at -78 deg C, giving the corresponding perfluoroalkyl ketones in good yields.
