112682-86-7Relevant academic research and scientific papers
Bi-directional alkyne tandem isomerization via Pd(0)/carboxylic acid joint catalysis: expedient access to 1,3-dienes
Cera, Gianpiero,Lanzi, Matteo,Bigi, Franca,Maggi, Raimondo,Malacria, Max,Maestri, Giovanni
supporting information, p. 14021 - 14024 (2019/01/03)
An in situ formed palladium hydride catalyst enables the sequential dual isomerization of propargylamide derivatives to 1-amido-1,3-dienes with high chemo- and regioselectivity. The reaction shows ample functional group tolerance, delivering a valuable class of products, including highly deuterated ones, from readily available reagents. The reaction occurs through a complex mechanism studied by DFT modelling.
