112683-81-5Relevant academic research and scientific papers
Structure-Activity Relationships of 8-Cycloalkyl-1,3-dipropylxanthines as Antagonists of Adenosine Receptors
Katsushima, T.,Nieves, L.,Wells, J. N.
, p. 1906 - 1910 (2007/10/02)
8-Substituted xanthines currently represent the most potent class of adenosine-receptor antagonists.A series of 8-substituted 1,3-dipropylxanthines was prepared and their potency as antagonists of A1 and A2 adenosine receptors of human platelets and rat a
8-Aryl- and 8-cycloalkyl-1,3-dipropylxanthines: Further potent and selective antagonists for A1-adenosine receptors
Shamim,Ukena,Padgett,Hong,Daly
, p. 613 - 617 (2007/10/02)
A series of 1,3-dipropylxanthines were prepared with a variety of substituents at the 8-position. These included 8-aryl and 8-cycloalkyl groups. Polar carboxylate and carboxamide moieties were introduced as aryl substituents to increase water solubility.
