1126894-07-2Relevant academic research and scientific papers
Exploiting the pyrazolo[3,4-d]pyrimidin-4-one ring system as a useful template to obtain potent adenosine deaminase inhibitors
Motta, Concettina La,Sartini, Stefania,Mugnaini, Laura,Salerno, Silvia,Simorini, Francesca,Taliani, Sabrina,Marini, Anna Maria,Settimo, Federico Da,Lavecchia, Antonio,Novellino, Ettore,Antonioli, Luca,Fornai, Matteo,Blandizzi, Corrado,Tacca, Mario Del
supporting information; experimental part, p. 1681 - 1692 (2010/02/16)
A number of pyrazolo[3,4-d]pyrimidin-4-ones bearing either alkyl or arylalkyl substituents in position 2 of the nucleus were synthesized and tested for their ability to inhibit adenosine deaminase (ADA) from bovine spleen. The 2-arylalkyl derivatives exhi
