1126896-41-0Relevant academic research and scientific papers
A Copper-Catalyzed Sonogashira Coupling Reaction of Diverse Activated Alkyl Halides with Terminal Alkynes Under Ambient Conditions
Cao, Yu-Xi,Dong, Xiao-Yang,Yang, Jun,Jiang, Sheng-Peng,Zhou, Shuangliu,Li, Zhong-Liang,Chen, Guo-Qiang,Liu, Xin-Yuan
, p. 2280 - 2284 (2020)
We describe a copper-catalyzed Sonogashira coupling reaction of alkyl halides with terminal alkynes under ambient conditions, efficiently providing a versatile tool for the construction of substituted alkynes. A new proline-based N,N,P-ligand is utilized to promote the transformation under a mild reaction condition. Diverse alkyl halides, such as primary and secondary (hetero)benzyl chlorides and bromides, secondary and tertiary α-bromo amides and propargylic bromide, are applicable to provide a wide array of alkynes. (Figure presented.).
Indium(III) catalyzed direct sp3-sp C-C bond formation from alcohols and terminal alkynes
Nan, Guangming,Zhou, Jun
, p. 555 - 561 (2014/01/06)
A simple and efficient indium(III)-catalyzed sp3-sp C-C bond formation reaction via direct coupling of alcohols with terminal alkynes has been developed under mild conditions without any ligand, base or additive, in which both of aromatic and aliphatic alkynes and various alcohols such as benzylic, allylic and propargylic alcohols can be tolerated. This simple reaction system provides an attractive approach to a large number of internal alkynes in moderate to good yields, and only generates H2O as the side product.
