112697-61-7

Usage

Chemical Class

Naphthyridine carboxamide

Biological Activity

Diverse range of activities, not extensively studied

Potential Pharmaceutical Applications

Medicinal chemistry

Structural Features

Methyl and phenyl groups on the nitrogen atom of the carboxamide moiety

Importance

Interesting target for further research and development due to potential influence on biological properties.

Upstream product

• 5174-88-9 2-methyl-1,8-naphthyridine-3-carboxylic acid ethyl ester 
• 62-53-3 aniline 
• 7521-41-7 2-Aminonicotinaldehyde 
• 102-01-2 N-phenylacetoacetamide 

Downstream Products

• 118965-57-4 2-Methyl-3-(1-phenyl-1H-tetrazol-5-yl)-[1,8]naphthyridine 

Relevant academic research and scientific papers

Indium(Iii) Chloride as an efficient catalyst for friedlander synthesis 1,8-Naphthyridines under solventfree conditions

InCl3 catalyzed Friedlander condensation of 2-aminonicotinaldehyde 1 with carbonyl compounds containing methylene group 2 has been achieved in solvent-free grinding conditions to give 1,8-naphthyridines 3 in high yields. The method is simple an

ZrOClinf2/inf.8Hinf2/infO catalyzed solvent-free Friedlander synthesis of 1,8-naphthyridines

ZrOClinf2/inf.8Hinf2/infO catalyzed Friedlander condensation of 2-Aminonicotinaldehyde 1 with carbonyl compounds containing-methylene group 2 has been achieved in solvent-free grinding conditions to give 1,8-naphthyridines 3. The yields are very good and

Cecl3.7H2O catalyzed Friedlander synthesis of 1,8-naphthyridines under solvent-free grinding conditions

CeCl3.7H2O catalyses the Friedlander condensation of 2-aminonicotinaldehyde 1 with varius carbonyl compounds containing α-methylene group 2 in solvent-free grinding conditions to afford the corresponding 1,8-naphthyridines 3. The rea

Green approach for the efficient synthesis of 1,8-naphthyridines promoted by citric acid

Citric acid catalyzed Friedlander condensation of 2-aminonicotinaldehyde 1 with various carbonyl compounds containing α-methylene group 2 has been achieved under neat conditions at 100° to give the corresponding 1,8-naphthyridines 3. The products are obta

An efficient Friedlander condensation using Zr(OH)2CO 3.ZrO2 as catalyst in the solid state

A simple and efficient Friedlander condensation of 2-aminonicotinaldehyde 1 with various carbonyl compounds containing α- methylene group 2 under solid state conditions to prepare 1,8- naphthyridines 3 in very good yields using Zr(OH)2CO3

Potassium triiodide catalyzed Friedlander synthesis of 1,8-naphthyridines in aqueous media

Potassium triiodide catalyses the Friedlander condensation of 2-aminonicotinaldehyde 1 with carbonyl compounds containing α-methylene group 2 in aqueous media to afford 1,-naphthyridines 3 in high yields.

Sulfamic acid: An efficient, cost-effective, and reusable solid acid catalyst for the synthesis of 1,8-naphthyridines under solvent-free heating and microwave irradiation

An efficient and convenient method is described for the synthesis of 1,8-naphthyridines in excellent yields by condensation of 2-aminonicotinaldehyde with various active methylene compounds in the presence of sulfamic acid as the catalyst in a solvent-free media using both conventional heating and microwave irradiation. Copyright Taylor & Francis Group, LLC.

Al2O3 catalyzed Friedlander synthesis of 1, 8-naphthyridines in the solid state

Al2O3 catalyzes efficiently the Freidlander condensation of 2-aminonicotinaldehyde 1 with various carbonyl compounds containing α-methylene group 2 in the solid state to afford the corresponding 1.8-naphthyridines 3. The reaction pro

Lithium chloride as an efficient catalyst for Friedlander synthesis of 1,8-naphthyridines via the use of microwave irradiation and pestle/mortar

An efficient, practical and eco-friendly method of preparation of 1,8-naphthyridines 3 has been reported by Friedlander condensation between 2-aminonicotinaldehyde 1 and active methylene compounds 2 in the presence of lithium chloride in combination with

Montmorillonite K 10 clay catalyzed Friedlander synthesis of 1,8-naphthyridines in dry media under microwave irradiation

Montmorillonite K 10 clay catalyzed Friedlander condensation of 2-aminonicotinaldehyde 1 with carbonyl compounds containing α-methylene group 2 has been achieved in solvent-free condition under microwave irradiation to give 1,8-naphthyridine derivatives 3