1127-29-3

Usage

Uses

Used in Mining Industry:
2,2,4,4-tetramethylcyclobutane-1,3-dione dioxime is used as a chelating agent for metal ions in the mining industry. It aids in the extraction and purification of metals like copper, cobalt, and nickel from ores due to its ability to form stable complexes with these metal ions.
Used in Analytical Chemistry:
In analytical chemistry, 2,2,4,4-tetramethylcyclobutane-1,3-dione dioxime is utilized for the determination and quantification of metal ions in various samples. Its chelating properties make it a valuable tool for accurate metal ion analysis.
It is important to handle 2,2,4,4-tetramethylcyclobutane-1,3-dione dioxime with care, as it may present health hazards if not properly managed.

InChI:InChI=1/C8H14N2O2/c1-7(2)5(9-11)8(3,4)6(7)10-12/h11-12H,1-4H3/b9-5-,10-6+

Upstream product

• 91858-95-6 N,N'-(2,2,4,4-tetramethylcyclobutanediyilidene)bis-t-butylamine-N,N'-dioxide 
• 121080-29-3 3-(hydroxyimino)-N,N'-(2,2,4,4-tetramethylcyclobutylidene)-t-butylamine N-oxide 
• 63196-50-9 2,4-Bis-tert-butylimino-1,1,3,3-tetramethyl-cyclobutane 
• 933-52-8 2,2,4,4-tetramethyl-1,3-cyclobutanedione 

Relevant academic research and scientific papers

NOVEL CYP17 INHIBITORS/ANTIANDROGENS

Compounds of formula (I), wherein R1 to R8 A, B, Z1 and Z2 are as defined in the claims and pharmaceutically acceptable salts and esters thereof are disclosed. The compounds of formula (I) possess utility as androgen receptor antagonists (inhibitors) and/or cytochrome P450 monooxygenase 17a-hydroxylase/17,20-lyase (CYP17) inhibitors. The compounds are useful as medicaments in the treatment of cancer, particularly prostate cancer, and other androgen dependent conditions and diseases where androgen antagonism is desired.

Imines and Derivatives. Part 21. A Study of Structural and Mechanistic Aspects of the Synthesis of Imine, Imine Oxide, and Oxime Derivatives of 2,2,4,4-Tetramethylcyclobutane-1,3-Dione by X-Ray Crystalography and Nuclear Magnetic Resonance and Ultraviolet Spectroscopy

The dinitrone derivatives (5a, b) of 2,2,4,4-tetramethylcyclobutane-1,3-dione were synthesised by peroxyacid oxidation of the corresponding di-imines (3a, b).X-ray crystallographic analysis of diimine (3a) and the hydroxyimino nitrone isomers (6a, b) indicate a marked buttressing effect leading to an exclusive preference for the trans geometry in di-imine (3a) and dinitrone (5a).Thermal elimination reactions of the N-But substituted nitrones (5a), (6a), and (8a) to yield oximes and 2-methylpropene have been investigated bu u.v. kinetic studies.The results areconsistent with a concerted mechanism involving a five-membered cyclic transition state.