1127217-38-2Relevant academic research and scientific papers
Rh(III)-catalyzed decarboxylative ortho -heteroarylation of aromatic carboxylic acids by using the carboxylic acid as a traceless directing group
Qin, Xurong,Sun, Denan,You, Qiulin,Cheng, Yangyang,Lan, Jingbo,You, Jingsong
, p. 1762 - 1765 (2015)
Highly selective decarboxylative ortho-heteroarylation of aromatic carboxylic acids with various heteroarenes has been developed through Rh(III)-catalyzed two-fold C-H activation, which exhibits a wide substrate scope of both aromatic carboxylic acids and heteroarenes. The use of naturally occurring carboxylic acid as the directing group avoids troublesome extra steps for installation and removal of an external directing group.
Establishment of broadly applicable reaction conditions for the palladium-catalyzed direct arylation of heteroatom-containing aromatic compounds
Liegault, Benoit,Lapointe, David,Caron, Laurence,Vlassova, Anna,Fagnou, Keith
scheme or table, p. 1826 - 1834 (2009/07/01)
Conditions for the palladium-catalyzed direct arylation of a wide range of heterocycles with aryl bromides are reported. Those conditions employ a stoichiometric ratio of both coupling partners, as well as a substoiehiometric quantity of pivalic acid, which results in significantly faster reactions. An evaluation of the influence of the nature of the aryl halide has also been carried out.
