112722-72-2Relevant academic research and scientific papers
A two step synthesis of 1,2,3-substituted pyrroles
Cunha, Anna C.,Pereira, Leticia O. R.,De Souza, Rodrigo O. P.,De Souza, Maria Cecilia B. V.,Ferreira, Vitor F.
, p. 3215 - 3226 (2000)
A method for preparing substituted pyrroles 3a-g in two steps from dihydrofurans 2a-b which were synthesized from α,α'-diazocarbonyl derivatives 1a-b was developed. The relevance of this research work lies in the easiness of preparing the substituted dihydrofurans and transforming them into pyrroles under mild conditions.
Electrochemical synthesis of 1,2,3-trisubstituted pyrroles from β-dicarbonyl compounds, aldehydes and amines via radical addition reaction
Chen, Wei-Jin,Yuan, Gao-Qing
supporting information, (2022/01/11)
An efficient electrochemical synthesis of 1,2,3-trisubstituted pyrroles was developed by one-pot three-component reaction of β-dicarbonyl compounds, aldehydes with amines. The target products could be obtained in good to excellent yields. Our investigations indicate that β-enamino ketone is a key intermediate in this transformation and the reaction mechanism may involve a radical addition reaction pathway.
A green and efficient one-pot synthesis of 1,2,3-trisubstituted pyrroles via iodine-catalyzed tandem reaction
Xu, Pengfei,Huang, Kunzhu,Cao, Dongsheng,Zeng, Wenbin
, p. 290 - 298 (2015/06/23)
A green, efficient and operationally simple method for three-component synthesis of 1,2,3-trisubstituted pyrrole derivatives via an iodine-catalyzed tandem reaction has been developed, and a series of 1,2,3-trisubstituted pyrrole derivatives were synthesized from simple starting materials under neutral conditions, with good to excellent yields in short time. This method showcased the potential of great value as a mild, rapid, and general procedure for the synthesis of 1,2,3-trisubstituted pyrroles.
An efficient and convenient synthesis of 1,2,3-trisubstituted pyrroles via iodocyclization from ethyl acetoacetate
Xu, Pengfei,Huang, Kunzhu,Liu, Zhiguo,Zhou, Ming,Zeng, Wenbin
, p. 2929 - 2933 (2013/06/27)
A novel and efficient methodology for the synthesis of 1,2,3-trisubstituted pyrroles by one-pot two-step reaction has been developed. The iodocyclization of a series of β-enamino esters followed by dehydroiodination, led to the formation of corresponding pyrroles. This approach provides an easy access to a wide range of 1,2,3-trisubstituted pyrroles.
