112734-97-1Relevant articles and documents
Bronchodilating pyrido?2,3-d!pyrimidine derivatives
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, (2008/06/13)
A rapid-acting remedy for asthma having a bronchodilating action contains at least one pyrido?2,3-d!pyrimidine derivative represented by the general formula (A) or pharmaceutically acceptable salts or metal complexes thereof as an effective component: STR1 wherein R1 and R2 are the same or different and each of R1 and R2 is hydrogen, alkyl or benzyl; R3 is hydrogen, hydroxyl, dialkylaminomethyleneamino or --NH--X; X is hydrogen, alkyl, alkenyl, hydroxyl, amino, hydroxyalkyl, benzyl or acyl; R4 is hydrogen, alkyl, halogen, nitro, amino, hydroxyl, benzyloxy, cyano, carboxyl, alkoxycarbonyl, alkoxysulfonyl, aminosulfonyl, dialkylaminosulfonyl or sulfo; and R5 is hydrogen, alkyl or amino. The rapid-acting remedy for bronchial asthma is capable of relieving the symptom of laboring breath at the onset of asthma due to its excellent bronchodilating action. It can be used as a therapy not only for allergic asthma but also for various bronchial asthmas such as endogenous asthma, exogenous asthma and dust asthma.