1127352-18-4Relevant academic research and scientific papers
A novel approach to combretastatins: From trans-epoxide to CA-4 and its dioxolane derivative
Lupattelli, Paolo,D'Auria, Maurizio,Di Blasio, Nadia,Lenti, Francesca
, p. 141 - 145 (2009)
The trans-epoxide derivative of Combretastatin A-4 was stereoselectively prepared in good yield by sulfur ylide mediated epoxidation of silyl-protected isovanillin. From this key intermediate, a formal synthesis of CA-4, by stereoselective deoxygenation and photoisomerization, was achieved. Alternatively, a trans-dioxolane derivative was obtained by stereoselective acetone insertion. Wiley-VCH Verlag GmbH & Co. KGaA, 2009.
