1127424-80-9Relevant academic research and scientific papers
Total synthesis of grandisine d
Kurasaki, Haruaki,Okamoto, Lwao,Morita, Nobuyoshi,Tamura, Osamu
supporting information; experimental part, p. 1179 - 1181 (2009/08/07)
Total synthesis of grandisine D (5) was achieved by a Bronsted acid mediated Morita-Baylis-Hillman (MBH) ring-closure reaction and stereoselective aldol condensation with (S)-5-methylcyclohexenone (9) as key steps. The MBH approach was also applicable for
A flexible approach to grandisine alkaloids: Total synthesis of grandisines B, D, and F
Kurasaki, Haruaki,Okamoto, Iwao,Morita, Nobuyoshi,Tamura, Osamu
experimental part, p. 12754 - 12763 (2010/06/14)
This article describes in detail the first total synthesis of grandisine alkaloids, grandisines B, D, and F, which show affinity for the human b-opioid receptor. The key steps in this synthesis are construction of the isoquinuclidinone moiety of 2 by intr
