112754-17-3

Basic information

• Product Name: 1-Bromo-2-pentafluoroethyl-benzene
• Synonyms: 1-Bromo-2-pentafluoroethyl-benzene
• CAS NO: 112754-17-3
• Molecular Formula: C₈H₄BrF₅
• Molecular Weight: 275.013376
• Mol File: 112754-17-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 173.2°C at 760 mmHg
• Flash Point: 58.6°C
• Appearance: /
• Density: 1.65g/cm³
• Vapor Pressure: 1.71mmHg at 25°C
• Refractive Index: 1.439
• CAS DataBase Reference: 1-Bromo-2-pentafluoroethyl-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-2-pentafluoroethyl-benzene(112754-17-3)
• EPA Substance Registry System: 1-Bromo-2-pentafluoroethyl-benzene(112754-17-3)

Safety Data

• Hazard Codes: T
• Statements: 10
• Safety Statements: 23-24/25
• TSCA: No
• Hazardous Substances Data: 112754-17-3(Hazardous Substances Data)

Usage

Physical state

Colorless, highly volatile liquid

Usage

Intermediate in organic synthesis

Chemical structure

Halogenated aromatic compound

Components

Pentafluoroethyl group and a bromine atom attached to a benzene ring

Natural occurrence

Not known to occur naturally

Production

Mainly produced in the laboratory for research and industrial purposes

Safety

Flammable and toxic

Health hazards

Can cause irritation to the skin, eyes, and respiratory tract

InChI:InChI=1/C8H4BrF5/c9-6-4-2-1-3-5(6)7(10,11)8(12,13)14/h1-4H

Upstream product

• 583-55-1 1-Bromo-2-iodobenzene 
• 124898-13-1 trimethyl(pentafluoroethyl)silane 

Relevant articles and documents

TMSCF3 as a Convenient Source of CF2=CF2 for Pentafluoroethylation, (Aryloxy)tetrafluoroethylation, and Tetrafluoroethylation

A new method for the on-site preparation of tetrafluoroethylene (TFE) and a procedure for its efficient use in pentafluoroethylation by fluoride addition were developed by using a simple two-chamber system. The on-site preparation of TFE was accomplished by dimerization of difluorocarbene derived from (trifluoromethyl)trimethylsilane (TMSCF3) under mild conditions. Other fluoroalkylation reactions, such as (aryloxy)tetrafluoroethylation and tetrafluoroethylation processes, were also achieved using a similar approach. This work not only demonstrates a convenient and safe approach for the generation and use of TFE in academic laboratories, but also provides a new strategy for pentafluoroethylation.

INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS

The present invention relates to compounds defined by formula (I) wherein the variables R1, R2, R3, m, and n are defined as in claim 1, possessing valuable pharmacological activity. Particularly, the compounds are activators of the receptor GPR40 and thus are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.